结直肠癌术后辅助化疗对血脂变化的影响

Serum lipid in colorectal cancer before and after chemotherapy

目的:探讨结直肠癌患者术后辅助化疗前后血脂水平的变化及不同化疗方案对血脂变化的影响。方法:对127例结直肠癌患者术后辅助化疗前后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平进行测定并比较分析。结果:化疗后,TG、HDL、LDL水平较化疗前升高,差异有统计学意义(P<0.05)。TC值较化疗前增高,但差异无统计学意义(P>0.05)。含奥沙利铂的化疗方案与卡培他滨单药方案相比对TC、TG、LDL的影响更加显著,差异有统计学意义(P<0.05)。结论:结直肠癌患者在术后辅助化疗期间存在血脂代谢紊乱,以血清TG、HDL、LDL升高为特点;不同化疗方案对血脂变化的影响存在差异。

Objective： To evaluate the level of serum lipid in colorectal cancer patients before and after chemotherapy. Methods： All 127 patients diagnosed with colorectal cancer were included in our study. Blood specimens were collected before and after chemotherapy. High density lipoprotein cholesterol and low density lipoprotein cholesterol were assessed by enzymatic kits. Results： The mean triglyceride,high density lipoprotein cholesterol and low density lipoprotein cholesterol were significantly higher after chemotherapy. Whereas,the mean total cholesterol was higher after therapy; but no statistically significance. In addition,significant difference on serum lipid alterations existed between capecitabine and the regimen containing oxaliplatin. Conclusion： The lipid metabolism disorders exist during chemotherapy in patients with colorectal cancer and the effects on serum lipid with different chemotherapy regimens are significantly distinct.