卵巢低储备导致卵巢低反应?

Could diminished ovarian reserve cause poor ovarian response?

在控制性卵巢刺激周期中,卵巢低反应（Poor Ovarian Response,POR）表现为卵巢对最大剂量的外源性FSH反应性下降,导致获卵数减少,妊娠率下降;POR与卵巢低储备有一定的相关性。但是卵巢储备功能的检测对卵巢反应性的预测能力有限,即便是在最理想的阈值时仍有10%-20%以上的假阳性率;首次IVF周期中卵巢对药物刺激的反应能够较好的提示卵巢的反应性,但前次卵巢低反应的患者再次发生POR的概率为62.4%。故卵巢低储备不一定导致卵巢低反应。

Poor ovarian response（POR）refers to poor response to ovarian stimulation during controlled ovarian stimulation cycles,which often leads to decline in number of oocyte retrieved and pregnancy rate.POR is often related to diminished ovarian reserve（DOR）.However,the value of the tests for ovarian reserve in predicting ovarian response is limited with a false positive rate of 10%-20%approximately.Ovarian response to ovarian stimulation in the first IVF cycle may reflect the ovarian response status,but the recurrent POR would happen in only 62.4% of the women with POR in subsequent cycles.In conclusion,diminished ovarian reserve does not necessarily lead to poor ovarian response.