摘要
生物三维打印成形的支架孔隙率对引导骨组织的再生极其重要。首先对不同孔径大小的骨组织工程支架模型进行有限元分析。再利用易降解、生物相容性良好的聚乙烯醇(PVA)与羟基磷灰石(HA)混合材料制备出不同孔隙率的骨组织工程支架,对其宏观特征、微观结构和力学性能等重要参数进行对比,得出孔隙率约为60%的骨组织工程支架实际平均抗压强度为14.90 MPa,力学性能与生物相容性最佳,为提高成骨效率奠定实验研究基础。
The porosity of the scaffold by the Biological 3DP is extremely important to guiding bone tissue regeneration. The bone tissue engineering scaffolds with different pore sizes were analysed by finite element method. Bone tissue engineering scaffolds with different porosity were prepared by using mixed materials, polyvinyl alcohol （PVA） and hydroxyapatite （HA） with easy degradation and good biological compatibility. And the important parameters of its macro characteristics,microstructure and mechanical properties are compared. It is concluded that the best porosity of mechanical properties and biocompatibility is about 60% , and the average compressive strength of the scaffold was 14.90 MPa. The research work of this paper establishes the experimental research foundation for improve the efficiency of bone formation.
出处
《机械设计与研究》
CSCD
北大核心
2016年第5期151-154,共4页
Machine Design And Research
基金
国家自然科学基金资助项目(51665055)
自治区高校科研计划资助项目(XJEDU2016I016)
关键词
三维打印
组织工程支架
孔隙率
羟基磷灰石
力学性能
three dimensional printing
Tissue engineering scaffold
Porosity
Hydroxyapatite （ HA ）
mechanical properties
