摘要
外周性性早熟（PPP）的病因复杂多样，主要分为遗传性或获得性2大类。McCune-Albright综合征和家族性男性性早熟为2类最主要的遗传性PPP。治疗该类疾病的主要目的是抑制第二性征的提前发育以及改善体内性激素水平，延缓骨骺闭合从而改善成年身高。目前临床用药主要包括抗雌／雄激素药物、雌激素受体阻滞剂、芳香化酶抑制剂、P450酶抑制剂等几大类。
The etiology of peripheral precocious puberty（PPP） is complex and varied,which is mainly catego- rized into either genetic or acquired disorders. Albright - McCune syndrome and familial male - limited precocious pu- berty are the 2 most important genetic PPPs. The purposes of therapy are to halt pubertal development and restore sex steroids to prepubertal values and delayed rate of skeletal maturation in order to maximize height potential. The several major categories of clinical drugs for PPP include anti estrogen/androgen, estrogen receptor blocker, aromatase inhibitors and cytochrome P450 inhibitors and so on.
作者
杨禄红
姚辉
Yang Luhong Yao Hui(Department of Endocrinology and Genetic Metabolism, Wuhan Women and Children＇s Medical Care Center, Wuhan 430016, China)
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2016年第20期1591-1594,共4页
Chinese Journal of Applied Clinical Pediatrics
