阿立哌唑治疗精神分裂症患者认知功能的效果观察

Observation of the Effects of Aripiprazole on the Cognitive Function of the Patients with Schizophrenia

目的观察阿立哌唑对精神分裂症患者认知功能的治疗效果。方法选取我院收治的精神分裂症92例患者,按照入院时间顺序的先后分两组,每组46例。对照组予氯丙嗪治疗,观察组予阿立哌唑治疗,对两组患者临床PANSS评分和认知功能予以评价。结果观察组患者治疗后的PANSS评分显著低于对照组,差异具有统计学意义(P<0.05);观察组治疗后韦氏成人智力表各项评分及临床记忆力评分均优于对照组(P<0.05)。结论针对精神分裂症患者,予以阿立哌唑治疗,其治疗效果显著,不但能提高患者的认知功能,且还能使患者的智力水平有所提高。

Objective To analyze the curative effects of apripiprazole on the cognitive function of the patients with schizophrenia. Methods 92 patients with schizophrenia who were admitted to our hospital were selected. According to the admission order, they were assigned to two groups, with 46 patients in each group.The control group was given chlorpromazine, and the observation group was given apripiprazole. The clinical curative effects and cognitive function were evaluated in the two groups of patients. Results PANSS scores in the observation group after the treatment were lower than those in the control group, and the differences were statistically significant（P〈0.05）; Wechsler adult intel- ligence scale and clinical memory score in the observation group after the treatment were both better than those in the control group（P〈0.05）. Conclusion For the patients with schizophrenia, the curative effects of apripiprazole are significant, which is not only able to improve patients’ cognitive function, but also able to improve patients＇ intelligence level.