度洛西汀与艾司西酞普兰治疗老年抑郁发作的对照研究

A comparative study of the treatment of elderly depressive episode with the degree of the treatment of the degree of Duloxetine and Escitalopram

目的 探讨度洛西汀与西酞普兰治疗老年性抑郁症的效果及不良反应。方法 选取2013年6月-2016年6月老年性抑郁症患者82例随机分成两组,研究组42例,给予度洛西汀治疗,对照组40例,给予艾司西酞普兰治疗,观察6周。在治疗前和在治疗后1、2、6周末分别评定两组汉密尔顿焦虑量表（HAMA）、副反应量表（TESS）、汉密尔顿抑郁量表（HAMD）。结果 共实际完成80例,完成率为97.6%;脱落2例,脱落率为2.4%,均发生在对照组;经过2周治疗后,两组HAMD、HAMA与治疗前比较,对照组优于研究组（P〈0.05）;6周后两组疗效比较,差异有统计学意义（P〈0.05）;采用TESS评估两组患者在治疗过程中出现药物不良反应,研究组出现不良反应率明显低于对照组,差异明显有统计学意义（P〈0.05）。结论 度洛西汀治疗老年精神分裂症疗效显著且副作用较少,值得推广应用。

Objective To explore the efficacy and adverse effects of Duloxetine and Citalopram in the treatment of senile depression.Methods 82 cases of senile depression patients from June 2013 to June 2016 were randomly divided into two groups,42 cases in the study group and were given Duloxetine for treatment,40 cases in the control group and were given Escitalopram for treatment,6 months of observation.Before treatment and at 1,2,6 weeks,Patients of two groups were assessed by Hamilton Anxiety Scale （HAMA）,side effects scale （TESS）,Hamihon Depression Scale （HAMD）. Results A total of 80 cases completed,the completion rate was 97.6%;2 cases of loss, the loss rate was 2.4%,occurred in the control group;after 2 weeks of treatment,two groups had obvious curative effect,the control group was better than that of study group（P〈0.05）;after 6 weeks,HAMD, HAMA of two group were compared to before treatment, the difference was siginificant （P〈0.05）;TESS side effects scale assessment of two groups of patients with adverse drug reactions in the treatment process,the adverse reaction rate of study group was significantly lower than that of control group,the difference was significant （P〈0.05）.Condusion The treatment of senile schizophrenia with the Duloxctine has a significant effect and less side effects,it is worth to apply.