磷酸肌酸钠、维生素C联合抗病毒治疗对病毒性心肌炎患儿心肌损伤的保护作用

Protective effect of creatine phosphate sodium,vitamin C combined with antiviral therapy on myocardial damage in children with viral myocarditis

目的:分析磷酸肌酸钠、维生素C联合抗病毒治疗对病毒性心肌炎患儿心肌损伤的保护作用。方法:141例病毒性心肌炎患儿根据治疗方式不同分为常规治疗组(常规抗病毒治疗)、联合治疗组(磷酸肌酸钠、维生素C联合抗病毒治疗),对比两组1个疗程后心肌损伤标志物、超声心动图参数、炎症因子、氧化/抗氧化指标差异。结果:联合治疗组治疗后血清心肌损伤标志物IMA、CK-MB、LDH、HBDH、cTNⅠ、MYO含量,超声心动图参数LAD、LVDD、RVDD、IVSD、RVOT值低于常规治疗组;血清炎症因子IL-10、IL-17、IL-23、IFN-γ含量低于常规治疗组;血清氧化指标NO、·OH、LPO、MDA含量低于常规治疗组,抗氧化指标SOD、SeGSH-Px含量高于常规治疗组。结论:磷酸肌酸钠、维生素C联合抗病毒治疗可积极保护病毒性心肌炎患儿的心功能,具体与其抗炎、抗氧化应激等作用相关。

Objective：To analyze the protective effects of creatine phosphate sodium,vitamin C combined with antiviral therapy on myocardial damage in children with viral myocarditis.Methods：A total of 141 children with viral myocarditis were divided into conventional treatment group（conventional antiviral therapy）and combined treatment group（creatine phosphate sodium,vitamin C combined with antiviral therapy）according to different treatment methods,and then the differences in myocardial damage markers,echocardiography parameters,inflammatory factors and oxidation/anti-oxidation indexes were compared between two groups after 1course of treatment.Results：Serum myocardial damage markers IMA,CK-MB,LDH,HBDH,cTNⅠ and MYO levels as well as echocardiography parameters LAD,LVDD,RVDD,IVSD and RVOT values of combined treatment group after treatment were lower than those of conventional treatment group;serum inflammatory factors IL-10,IL-17,IL-23 and IFN-γlevels were lower than those of conventional treatment group;serum oxidation indexes NO,·OH,LPO and MDA levels were lower than those of conventional treatment group while anti-oxidation indexes SOD and SeGSH-Px levels were higher than those of conventional treatment group.Conclusion：Creatine phosphate sodium,vitamin C com-bining with antiviral therapy can actively protect the cardiac function of children with viral myocarditis,which is specifically related to its effect such as anti-inflammation and anti-oxidative stress.