频域OCT检测mGCC厚度在原发性青光眼诊断中的应用进展

Application in diagnosis of primary glaucoma by macular ganglion cell complex thickness measurement with spectral-domain OCT

青光眼是一种具有特征性视神经损害和视野缺损的不可逆致盲眼病,其早期诊断、早期治疗是决定预后的关键。黄斑区视网膜神经节细胞复合体(macular ganglion cell complex,m GCC)由黄斑区视网膜的内三层结构组成,包括视网膜神经纤维层(nerve fiber layer,RFL)、神经节细胞层(gangalion cell layer,GCL)和内丛状层(inner plexiform layer,IPL),它是青光眼结构损害的靶组织,有助于青光眼的早期诊断。光学相干光断层扫描(optical coherence tomography,OCT)具有非接触性、可重复性好、获取眼部图像快等优点,已在眼科领域广泛应用。频域OCT能提供更高的图像分辨率,可对黄斑区视网膜神经节细胞复合体(m GCC)的厚度进行精确测量,为青光眼的早期诊断提供了新参数。

Glaucoma is a group of irreversible blind eye diseases with specific optic nerve damage and visual field defect. Early diagnosis and treatment of glaucoma is vital for prognosis, but difficult in clinical practice. Macular ganglion cell complex thickness（mGCC） consists of the inner three layers of retina：retinal nerve fiber, ganglion cell and inner plexiform layers, which is glaucoma target tissue so to be measured the thickness of the mGCC as better indicator for early diagnosis in glaucoma. Optical coherence tomography （ OCT ） is a non-contact, good repeatability technique to obtain fast high- resolution images from the anterior and posterior segments of the eye, and it has been widely used in ophthalmology. Spectral- domain （ SD ） OCT allows a higher image resolution and can measure the thickness of mGCC thickness, providing new parameters for the early diagnosis of glaucoma.