特发性肺间质纤维化合并肺气肿与未合并肺气肿患者的比较研究

Idiopathic Pulmonary Fibrosis Merger Emphysema and Comparative Study of Unincorporated Emphysema Patients

目的探讨特发性肺间质纤维化合并肺气肿临床特点、影像学、肺功能等差异。方法观察组特发性肺间质纤维化合并肺气肿患者45例。对照组抽取同期单纯特发性肺间质纤维化未合并肺气肿患者44例。比较两组临床资料、肺功能、支气管肺泡灌洗液细胞成分、血氧分压、生存时间等。所获数据采用方差分析,t检验和X^2检验。结果两组肺总量占预计值、一氧化碳弥散量占预计值百分比比较,P<0.05,有显著性差异。两组支气管肺泡灌洗液细胞总数、淋巴细胞比较,P>0.05,无显著性差异。结论特发性肺间质纤维化合并肺气肿与否对预后没有影响。吸烟是造成特发性肺间质纤维化主要原因。

Objective To study the combination of emphysema and idiopathic pulmonary interstitial fibrosis of unincorporated emphysema patients clinical characteristics, imaging and lung function. Methods 45 patients with idiopathic pulmonary fibrosis merger emphysema, as observation group. Extraction period pure idiopathic pulmonary interstitial fibrosis, 44 patients with unincorporated emphysema, as control group. Compare two groups of clinical data, pulmonary function, bronchial alveolar lavage fluid components, blood oxygen partial pressure, survival time, etc. The data obtained using analysis of variance, t test and χ2 test. Results Two groups of total lung （estimated value percentage, carbon monoxide diffusion capacity （expected value percentage comparison, P〈0.05, there is significant difference. Two groups of bronchoalveolar lavage fluid total number of cells, lymphocytes, P〉0.05, no significant difference. Conclusion Idiopathic pulmonary fibrosis merger emphysema or not has no effect on the prognosis. Smoking is a major cause, idiopathic pulmonary fibrosis.