精神分裂症发病危险因素224例

Pathogenic Factors in 224 Cases of Schizophrenia Research

目的探讨精神分裂症患者的发病危险因素。方法观察组为首次住院的精神分裂症患者224例,对照组选取正常查体224例,应用自制的调查表及生活事件量表(LES)进行调查。所获数据采用方差分析、t检验和X^2检验。结果两组遗传史因素比较,X^2=65.37,P<0.01有显著性差异;性格内向两组间比较,X^2=67.13,P<0.01,有显著性差异;两组冬季出生者比较,X^2=9.44,P<0.01,有显著性差异。两组母孕期感染、病理性分娩、新生儿期及婴幼儿期疾病的比较,P<0.01,有显著性差异。两组母孕期接触毒害因素、出生时体重<2500克者的比较,P<0.05,有显著性差异。胎次高,患病风险大,C=6.22,P<0.01。两组早期父母死亡者,X^2=3.1818;P<0.05,有显著性差异;父母采取溺爱娇惯者X^2=19.370,P<0.005,有非常显著性差异;要求过高过严教育方式者X^2=11.241,P<0.005,有极非常显著性差异。两组患病前1年内生活变化单位(LEU)分值比较,t=9.2419,P<0.001。结论:精神分裂症的发病危险因素涉及多个方面,应采取综合防治措施。

Objective To investigate the risk factors of patients with schizophrenia. Methods Observation group for the first time in our hospital 224 cases of schizophrenia patients in hospital, control group selected 224 cases of normal physical examination, application of self-made questionnaires and life events scale （LES） were investigated.The data obtained using analysis of variance, t test and χ2 test. Results Two groups of genetic history factor comparison, χ2 = 65.37, P〈0.01 there are significant differences; Introverted comparison between the two groups, the χ2 = 67.13, P〈0.01, there is significant difference. Born in winter, the two groupsχ2= 9.44, P〈0.01, there is significant difference. Two groups of maternal infection during pregnancy, pathological childbirth, the neonatal period and childhood illness comparison, P〈0.01, there was significant difference. Two groups of female contact poison factors during pregnancy, birth weight of 2500 grams of comparison, P〈0.05, there is significant difference.Times higher, the risk is big, C=6.22,P〈 0.01. Two sets of parents early death, χ2 = 3.1818, P〈 0.05, there are significant differences; Parents take spoil spoil Z 2 = 19.370, P〈0.005, there is a very significant difference; Too high a strict education methods χ= 11.241, P〈0.005, there is a very significant difference. Two groups of sick 1 years before life change units （LEU） score, t = 9.2419, P〈 0.001. Conclusion The onset of schizophrenia risk factors involved in various aspects, comprehensive prevention and control measures should be taken.