功能性消化不良患者血浆神经肽Y和P物质水平与焦虑抑郁情绪的相关性

Correlation of plasma neuropeptide Y and substance P levels with anxiety and depression in patients with functional dyspepsia

目的：探讨功能性消化不良（FD）患者血浆神经肽Y（NPY）和P物质（SP）水平与焦虑抑郁情绪的相关性。方法通过采用焦虑自评量表（SAS）和抑郁自评量表（SDS）评定30例FD患者和30名健康志愿者的焦虑抑郁水平。采集受试者外周血，采用酶联免疫吸附法（ ELISA）检测血浆中NPY和SP的水平。结果健康对照组 NPY 和 SP 水平分别为（118．53±22．29） ng／L 和（47．65±11．06）ng／L，FD组NPY和SP水平分别为（94．82±18．53）ng／L和（35．16±8．42）ng／L，差异有统计学意义（t ＝8．13，7．04；P＜0．01）。 FD组SAS和SDS评分分别为（67．4±14．2）分和（63．9±13．5）分，健康对照组分别为（44．6±11．7）分和（41．1±10．6）分，差异有统计学意义（t ＝12．44，11．18；P＜0．01）。 FD患者和伴焦虑抑郁情绪FD患者在性别、年龄和病程时间方面差异无统计学意义（χ2＝1．22，0．56，2．14；P＞0．05）。 FD患者血浆NPY水平与SAS和SDS评分均呈负相关（r＝－0．70，－0．61， P＜0．01），FD患者血浆SP水平与SAS和SDS评分均呈负相关（r ＝－0．74，－0．56；P＜0．01）。结论 FD患者血浆NPY和SP水平降低，并且与焦虑抑郁评分呈负相关性，NPY和SP可能在伴焦虑抑郁情绪功能性消化不良发病机制中起重要作用。

Objective To investigate the correlation between plasma neuropeptide tyrosine （ NPY） and substance P （ SP ） levels and anxiety and depression in patients with functional dyspepsia （ FD ） . Methods Anxiety and depression scores of 30 patients with FD and 30 healthy volunteers were obtained by self-rating anxiety scale （ SAS） and self-rating depression scale （ SDS） .The peripheral blood of participants was collected and the enzyme-linked immunosorbent assay （ ELISA） was used to detect the levels of plasma NPY and SP.Results The levels of NPY and SP were （94.82±18.53）ng/L and （35.16±8.42）ng/L in the FD group respectively,and were （118.53±22.29）ng/L and （47.65±11.06）ng/L in the healthy controls respectively,the differences were statistically significant （t=8.13,7.04;P〈0.01） .SAS and SDS scores were （67.4±14.2） and （63.9±13.5） in the FD group respectively,and were （44.6±11.7） and （41.1±10.6） in the healthy controls respectively,the differences were statistically significant （t =12.44,11.18;P〈0.01） . There were no significant differences in gender, age and disease duration between FD patients and FD patients with anxiety and depression（χ2=1.22,0.56,2.14;P〉0.05） .The plasma NPY levels in FD patients 〈br〉 were negatively correlated with SAS and SDS scores （r =-0.70,-0.61;P〈0.001） .The plasma SP levels in FD patients were negatively correlated with SAS and SDS scores （ r =-0.74,-0.56; P 〈0.01 ） . Conclusions The levels of plasma NPY and SP in FD patients are reduced,and negatively correlated with anxiety and depression scores.SP and NPY may be involved in the pathogenesis of functional dyspepsia with anxiety and depression.