催产素与米索前列醇治疗产后出血的临床效果评价

Clinical effect evaluation of oxytocin and misoprostol for treatment of postpartum hemorrhage

目的 观察并评估催产素和米索前列醇对产后出血的临床治疗效果。方法 参照完全随机数表方法,将2014年11月至2015年12月我院收治的产后出血患者120例分为对照组（单纯催产素治疗）和观察组（催产素联合米索前列醇治疗）,每组60例,对比两组患者的临床治疗效果。结果 观察组的子宫收缩能力有效率为93.33%,明显高于对照组水平,差异具有统计学意义（字2=8.65;P〈0.05）;观察组的止血时间和产后出血量分别为（19.57±4.32）min、（456.48±65.39）m L,均明显低于对照组,差异具有统计学意义（t=13.75,14.22;P〈0.05）;观察组的不良反应率为3.33%,明显低于对照组（字2=5.68,P〈0.05）。结论 催产素联合米索前列醇治疗产后出血的疗效确切,能显著缩短产后出血时间,降低出血量,且有利于宫缩能力的提高与恢复,值得临床推广应用。

Objective To observe and evaluate the clinical effect of oxytoein and misoprostol on postpartum hemorrhage. Methods One hundred and twenty cases of patients with postpartum hemorrhage were divided into control group （simple oxytoein treatment） and observation group （oxytoein combined with misoprostol treatment） according to the random number table, with 60 patients in each group. The clinical treatment effect of the two groups were compared. Results The uterine contraction capacity effective rate of the observation group was 93.33%, which was better than that of the control group, the difference was statistically significant （x^2=8.65, P〈0.05）.The hemostatic time and postpartum bleeding volume of the observation group were（19.57±4.32） min and（456.48±65.39） mL respectively, which were significantly better than those of the control group, the differences were statistically significant （t =13.75,14.22; P〈0.05）. The adverse reaction rate of the observation group was 3.33%, which was significantly lower than that of the control group （x^2=5.68, P〈0.05）. Conclusion Oxytocin combined with misoprostol in the treatment of postpartum hemorrhage can significantly shorten the time of postpartum hemorrhage, reduce the amount of bleeding and is conducive to the improvement of contraction ability, which has a significance and value in clinical application.