泌尿系置管与绿脓杆菌感染及耐药的相关性分析

Analyze risk factors and multi- drug resistance for catheter associated urinary tract pseudomonas aeruginosa infection

目的探讨泌尿系置管患者发生绿脓杆菌感染的相关因素,分析其多重耐药原因。方法统计2015年3月至2016年3月在我科行泌尿系置管的1536患者的病历资料,其中14例发生绿脓杆菌感染,记录与分析与感染发生有关的各种条件和药敏情况。结果 14例中12例为男性,占85.7%,体外置管、留置管时间超过1月、术前肾功能受损患者发生绿脓杆菌感染的机会明显增加,药敏提示呈多重耐药菌,仅对环丙沙星、头孢他啶、哌拉西林/他唑巴坦、丁胺卡那霉素、亚胺硫霉素敏感。结论合并慢性疾病,尤其是肾功能受损的患者,泌尿系外引流管超过一个月,发生耐药绿脓杆菌感染的概率明显增加。

Objective To study risk factors and multi- drug resistant situation of catheter associated urinary tract pseudomonas aeruginosa infection. Methods 1536 cases of patients received urinary catheterization in our hospital from March 2015 to March 2016 were enrolled. Among these cases,the relevant factors of multi- drug resistant situation in 14 case with pseudomonas aeruginosa infection were analyzed. Results Total 14 cases,in which 12 cases were male（ account for 85. 7%）,were multi- drug resistant. Moreover,infection rate in cases with impaired renal,long- time indwelling catheter or catheter in vitro increased significantly. Finally,Multi-drug resistant pseudomonas aeruginosa were sensitive to topiperacillin,tazoobactam,ciprofloxacin,amikacin,ceftazidime,imipenem resepectively. Conclusion The rate of pseudomonas aeruginosa infection in cases with chronic diseases,especially impaired renal and urinary system once established outside the drainage tube more than a month,was significantly increased.