2180名武汉市居民幽门螺杆菌感染现状及危险因素分析

An Epidemiological Study of Helicobacter Pylori Infection and Its Risk Factors in 2 180 Wuhan residents

目的：了解武汉市居民幽门螺杆菌的感染率及其危险因素。方法对武汉市2180名居民进行尿素14C呼气试验测定，同时运用调查表进行相关生活方式的调查。结果2180名健康体检居民中，尿素14C呼气阳性者为1025名，幽门螺杆菌的感染率为47.02%。多因素Logistic回归分析显示，男性感染幽门螺杆菌风险是女性的1.38倍（95%CI：1.07~1.69），家庭共用公筷（OR=0.78）、大专或以上文化程度（OR=0.70）是减少幽门螺杆菌感染的主要因素（P〈0.01）。结论武汉市健康居民中活动性幽门螺杆菌的感染率较高，家庭共用公筷进餐是减少幽门螺杆菌感染的有效措施之一，因此有关部门应提倡使用公筷，预防及减少幽门螺杆菌的感染。

Objective To understand the risk factors of Helicobacter pylori （Hp） infection and its risk factoes in Wuhan. Methods We conducted a study by 14C urea breath test and a lifestyle questionnaires survey among 2,180 Wuhan residents. Results It was found that 14C urea breath test was positive in 1,025 out of 2,180 residents who completed the survey. The positive rate of Hp infection was 47.02%among Wuhan residents. Males had statistically significant higher infection rate than that of females （ P〈0.01）, with an odds ratio （OR） of 1.38 and 95% confidence interval （CI） of 1.07~1.69. Non-conditional logistic regression analysis in the final multivariate model showed family with serving chopsticks （OR=0.78）, and college education or above （OR=0.70） were the main protective factors for Hp infection （P〈0.01）. Conclusion The prevalence of Hp infection is higher in males than that in females in Wuhan residents. Family with serving chopsticks and higher education level may reduce the rate of Hp infection. It is necessary to promote the use of serving chopsticks to prevent and reduce Hp infection.