韶关市埃可病毒30型流行区与非流行区人群中和抗体水平

ECHO30 neutralizing antibody levels of endemic and non-endemic areas of Shaoguan

目的了解韶关市健康人群埃可病毒30型(ECHO30)的中和抗体水平。方法采用中和抗体法检测流行区与非流行区人群ECHO30中和抗体,并将两区人群的检测结果进行比较。结果流行区人群ECHO30中和抗体阳性率、几何平均滴度、高滴度者所占比例分别为99.27%、(97.53±0.65)、66.78%,均高于非流行区的97.94%、(48.61±0.65)、55.15%,除中和抗体阳性率外,其余两项差异有统计学意义(t=-5.02,P=0.000;χ2=6.61,P=0.010)。流行区不同年龄人群几何平均滴度以5岁内婴幼儿最高,且随年龄增长呈下降趋势(F=3.660,P=0.006)。非流行区人群ECHO30中和抗体阳性率、几何平均滴度均以5岁内婴幼儿最低,但年龄组间差异均无统计学意义(χ2=8.38,P=0.079;F=1.344,P=0.255)。结论流行区发生的病毒性脑炎暴发是由ECHO30所致,人群ECHO30感染普遍,小于5岁的婴幼儿易感,应加强监测工作。

Objective To investigate the neutralizing antibody levels of Echovirus 30（ECHO30） in healthy population of Shaoguan. Methods ECHO30 Neutralizing antibody levels ofendemic and non-endemic areas were determined. Results The ECHO30 neutralizing antibody positive rate, GMT, the proportion of people with GMT ≥ 1 ：64 in endemic areas were 99.27%,（97.53 ±0.65） and 66.78%,respectively, which were significantly higher than those of the non-endemic area [97.94%,（48.61±0.65） and 55.15%,respectively）（χ^2=0.786,P=0.375;t=-5.02,P=0.000; χ^2=6.61, P=0.010）.In endemic areas, GMT in 5 years old group showed the highest value and decreased with increasing age. On the contrary, the non-endemic areas showed the lowest level in ECHO30 neutralizing antibody positive rate and GMT in the5 years old group, however no significant differences were found among different age groups.（χ^2=8.38,P =0.079; F =1.344,P=0.255）. Conclusions The outbreaks of viral encephalitis was caused by the ECHO30 inendemic areas. The infection of ECHO30 was widespread in population, especially under 5 years old.We should strengthen the monitor and control of the disease.