丁基苯酞序贯治疗对急性脑梗死患者临床疗效的观察

Clinical curative observation of butyl phthalide sequential treatment of acute cerebral in- farction

目的：观察丁基苯酞序贯治疗急性脑梗死的临床疗效。方法：选取2015年6月-2016年3月本院收治的脑梗死患者60例，随机分为丁基苯酞组和对照组，各30例。两组均给予脑梗死的常规用药治疗及运动疗法，治疗组加用丁基苯酞序贯治疗（丁苯酞注射液100mL 2／d，静脉静点，疗程为2周，后改为丁苯酞软胶囊0．2g3／d，日服，疗程为10周）。观察对比两组治疗前后的神经功能缺损程度量表评分（NIHSS）及日常生活能力（Barthel，BI）情况。结果：两组连续治疗2、8、12周后NIHSS评分较治疗前均有降低，差异有统计学意义（F=203．243，715．75（3，P〈0．01），且丁基苯酞组疗效优于对照组（P〈0．05）；两组连续治疗2周、12周后B1评分较治疗前均提高，差异有统计学意义（F=83．582，36．417，P〈0．01），治疗2周时丁基苯酞组及常规组治疗效果相同，差异无统计学意义（P〉0．05），连续治疗12周后丁基苯酞组疗效优于常规组，差异有统计学意义（P〈0．01）。结论：丁基苯酞序贯疗法治疗急性脑梗死可延缓神经功能的缺损，改善患者的生活能力，值得在临床上应用。

Objective：To observe the elinical effect of butyl phtilalide sequential treatment of acute cerebral infarction. Methods：From June 2015 to March 2016,60 patients with acute cerebral infarction were selected and randondy divided into the treatment group and the control group, with 30 cases in each group. The two groups were all given conventional drug therapy of cerebral infarction and exercise thera py,while the treatmem group was added with butyl phthalide sequential treament（100 mL, twice per day, intravenous drip for two weeks,and then 0.2 g three times a day,oral for ten weeks）. The degree of neural function defect score（ NIHSS）and daily life ability score（Barthel index BD were compared respectively between the two group〉 just before and after ircatmcnl. Results： Compared with those in pretreat ment,the NIHSS of postreatment in the second eighth and twelfth weeks decreased（F 203. 243, 715. 750,P〈0.01）,and in the treatment group were significantly better than in the control group,and the difference was statistically significant（P〈0. 05）; Compared with that pretreatment, the BI of pos- treatment at the second and twelfth weeks was improved,and the difference was statistically significant（F =83. 582,36. 417, P〈0. 01 ）, the curative effect of the two groups were the same in the second week and the difference was not statistically significant（P〉0.05 ）, while the treatment group was significantly bet ter than the control group in the twelfth week,and the difference was statistically significant（P〈0.01 ）. Conclusion： Butyl phthalide sequential treatment can delay nerve function damage and improve the patients ability of daily life. It is worth of clinical application.