血清S100A8和S100A9对原发性肝癌的临床诊断价值

Analysis of Diagnostic Value of Serum Levels S100A8 and S100A9 for Hepatocellular Carcinoma

目的探讨原发性肝癌患者血清S100A8和S100A9的表达水平及其与临床病理特征的相关性。方法收集原发性肝癌患者共90例,同期选择在我院进行体检健康者50例作为对照组;检测2组血清S100A8和S100A9的水平;分析肝癌患者血清S100A8和S100A9水平与临床病理特征的相关性;比较随访期间死亡组与存活组患者血清S100A8和S100A9表达。结果与对照组比较,肝癌组患者血清S100A8和S100A9均显著升高(P<0.01)。肝癌患者血清S100A8和S100A9的高表达与患者的年龄、性别、大小、病理分型无关(P>0.05),而与TNM分期、分化程度、淋巴结转移以及血行转移有关(P<0.01)。所有患者6个月定期随访,31例死亡,59例存活;死亡组患者入院时血清S100A8和S100A9表达均显著高于存活组,差异有统计学意义(P<0.01)。结论原发性肝癌患者血清S100A8和S100A9水平均显著升高,与肝癌的恶性程度关系密切,有望成为原发性肝癌预后的重要评判指标。

Objective To investigate serum levels of S100A8 and S100A9 of hepatocellular carcinoma and its correlation with clinicopathological characteristics.Methods 90 cases of hepatocellular carcinoma were selected,and 50 healthy patients were the control group.Serum levels of S100A8 and S100A9 in hepatocellular carcinoma group and the control group were detected.Correlation of serum levels of S100A8 and S100A9 in hepatocellular carcinoma and clinicopathological characteristics was analyzed.Serum levels of S100A8 and S100A9 between death group and survival group were compared.Results Compared to the control group,serum levels of S100A8 and S100A9 of hepatocellular carcinoma obviously increased（P〈0.01）.Serum levels of S100A8 and S100A9 in hepatocellular carcinoma were no correlated with age,gender,size,and pathological type（P〉0.05）,but were correlated with TNM stage,differentiation degree,lymph node metastasis,and hematogenous metastasis（P〈0.01）.After follow up of 6 months,there had 31 death and 59 survival,and serum levels of S100A8 and S100A9 in death group were remarkably higher than those of survival group,there had statistical difference（P〈0.01）.Conclusion Serum levels of S100A8 and S100A9 of hepatocellular carcinoma obviously increased,and are closely related with malignancy grade of hepatocellular carcinoma,and it could be important indicator for prognosis of hepatocellular carcinoma.