胰岛素样生长因子及其结合蛋白在Ⅰ期非小细胞肺癌中的诊断价值

The Diagnostic Value of Insulin-like Growth Factor and Its Binding Protein in Stage Ⅰ Non-small Cell Lung Cancer

目的探讨胰岛素样生长因子及其结合蛋白在Ⅰ期非小细胞肺癌中的诊断价值。方法选择98例肺部病变患者为研究对象,根据病变程度分为良性病变组和Ⅰ期NSCLC组,采用ELISA方法测定所有患者血清中IGFBP-1~IGFBP-7、IGF-1和IGF-2的水平,比较2组间各水平的差异;进一步分析差异指标与Ⅰ期NSCLC临床参数的关系,并进行差异指标间的相关性分析。结果良性病变组的IGFBP-3和IGFBP-5的水平高于Ⅰ期NSCLC患者的水平,IGF-1、IGF-2的水平低于Ⅰ期NSCLC组,差异均具有统计学意义（P〈0.05）。而IGFBP-1、IGFBP-2、IGFBP-4、IGFBP-6、IGFBP-7、IGF-1/IGFBP-3、IGF-2/IGFBP-3在2组之间无统计学差异（P〉0.05）。Ⅰ期NSCLC组中IGFBP-3、IGFBP-5、IGF-1、IGF-2的水平在肿瘤大小、淋巴结转移的有无、分化程度等临床参数分层之间具有统计学差异（P〈0.05）。相关性的结果显示IGFBP-3、IGFBP-5与IGF-1、IGF-2均呈明显负相关;IGF-1与IGF-2,IGFBP-3与IGFBP-5呈明显正相关。结论胰岛素样生长因子（IGF-1和IGF-2）及胰岛素样生长因子结合蛋白（IGFBP-3和IGFBP-5）在Ⅰ期非小细胞肺癌中具有重要的诊断价值。

Objective To evaluate the diagnostic value of insulin-like growth factor and its binding protein in stage Ⅰnon-small cell lung cancer（NSCLC）.Methods 98 lung disease patients were divided into stage Ⅰ NSCLC group and benign group according to the severity of lung disease.The levels of IGFBP-1 to IGFBP-7 and IGF-1 as well as IGF-2 in serum were measured by ELISA and compared between the 2 groups.Further analysis of relation between different index and clinical parameters were carried out,along with the correlation among these different index.Results The levels of IGFBP-3 and IGFBP-5 in benign group were higher than those of stage Ⅰ NSCLC group,while the levels of IGF-1 and IGF-2 were lower than those in stage ⅠNSCLC group,there had statistically significant differences（P〈0.05）.The levels of IGFBP-1,IGFBP-2,IGFBP-4,IGFBP-6,IGFBP-7,IGF-1/IGFBP-3,IGF-Ⅱ/IGFBP-3 had no significant difference between the 2 groups（P〉0.05）.The levels of IGFBP-3,IGFBP-5,IGF-1 levels,IGF-2 in stage Ⅰ NSCLC group had statistically significant difference in clinical parameters such as tumor size,lymph node metastasis presence or absence and differentiation（P〈0.05）.Correlation analysis showed both IGFBP-3and IGFBP-5 had negative correlation with IGF-1and IGF-2.And IGF-1 was positively correlated with IGF-2,as well as IGFBP-3with IGFBP-5.Conclusion Insulin-like growth factor（IGF-1 and IGF-2） and insulin-like growth factor binding protein（IGFBP-3 and IGFBP-5） has important diagnostic value for stage Ⅰ NSCLC.