艾滋病鸡尾酒疗法引发心血管疾病研究进展

Progressin the Study of Antiretroviral Therapy Related Cardiovascular Diseases in AIDS Patients

鸡尾酒疗法,也被称作高效抗逆转录病毒疗法(antiretroviral therapy,ART),使得艾滋病成为临床上的一种可控疾病。但是越来越多的证据显示了接受鸡尾酒疗法的HIV(human immunodeficiency virus)阳性病人心血管疾病的发病率很高。在众多可能导致HIV阳性病人高心血管发病率的因素中,除了免疫缺陷以及代谢紊乱之外,鸡尾酒疗法的副作用越来越引起人们的重视。目前,针对ART药物在心血管方面的影响主要关注其主干药物核苷类逆转录酶抑制剂与蛋白酶抑制剂的副作用。该文就这两种药物在心血管疾病方面的相关研究进展进行了综述。

The successful roll-out of antiretroviral therapy（ART） makes HIV infection into a manageable clinical entity. However, more and more clinical evidences define an elevated risk of developing cardiovascular disease（CVD） among HIV-positive patients who are with medical care. Beside immunological defect and metabolic disorder, adverse effects of antiretroviral therapy have become of particular concern within factors that may potentially contribute to HIV-related CVD. Currently, the effects of ART on cardiovascular disease are mainly linked with two kinds of backbone drugs, nucleoside reverse transcriptase inhibitors（NRTIs） and protease inhibitors（PIs）. The aim of this review is to introduce the research progresses of ART related cardiovascular diseases in AIDS patients.