PM_(2.5)对呼吸系统损伤的流行病学和机制研究进展

Research Progress of Epidemiology and Mechanism of PM_(2.5) on the Damage of Respiratory System

机体暴露于空气污染细颗粒物(PM_(2.5))可引起多种健康损害。PM_(2.5)可直接作用于呼吸系统,穿过血气屏障,与机体各种疾病发病密切相关。从流行病学、动物实验研究等方面了解PM_(2.5)对呼吸系统不同程度的损伤及其毒性机制的复杂性,从而为更深入研究PM_(2.5)的毒性机制,以及PM_(2.5)与肿瘤相互作用机制等前沿问题提供科学依据,为相关疾病的预防和治疗提供依据。

Body exposure to fine particulate matter air pollution （PM2.5） can cause a variety of health damage. PM2.5 can act directly on the respiratory system and through the blood barrier, which is closely related to the body＇s various diseases. This paper elaborated possible mechanism of PM2.5 on the respiratory system as well as varying degrees of damage,pointed out the mechanism of toxicity, and a more in-depth toxicity mechanism from epidemiological studies. Meanwhile, this paper provides a scientific basis about PM2.5 and other cutting-edge issues.