舒血宁注射液对脑梗死伴肺感染患者血流变学与Lp-PLA2水平的影响

Influence of Shuxuening injection for the hemorheology,Lp-PLA2 level in patients with cerebral infarction and pulmonary infection

目的研究及观察舒血宁注射液对脑梗死伴肺感染患者血流变学、Lp-PLA2水平及神经功能缺损的影响,以为脑梗死伴肺部感染患者的治疗方式选取提供依据。方法选取2013年12月-2015年11月医院收治46例脑梗死伴肺感染患者为研究对象,将其根据随机分配的方式分为对照组和观察组各23例,对照组进行常规脑梗死伴肺感染治疗,观察组在对照组的基础上加用舒血宁注射液,然后将两组患者治疗前和治疗后7、14d时的血流变学、血浆Lp-PLA2水平及神经功能相关血清指标进行比较。结果治疗前两组患者的血流变学、血浆LpPLA2水平及神经功能相关血清指标均差异无统计学意义,而治疗后7d及14d时,观察组血浆黏度、全血低切黏度及全血还原低切黏度分别为(1.34±0.12)mPa·s、(8.98±0.84)mPa·s、(20.21±1.64)mPa·s及(1.10±0.08)mPa·s、(7.82±0.75)mPa·s、(18.10±1.25)mPa·s,其均低于对照组(1.78±0.18)mPa·s、(11.21±1.30)mPa·s、(22.45±1.82)mPa·s及(1.45±0.13)mPa·s、(9.94±0.89)mPa·s、(20.46±1.70)mPa·s,其他血流变指标、血浆Lp-PLA2水平及神经功能相关血清指标也均低于对照组,差异有统计学意义(P<0.05)。结论舒血宁注射液可有效改善脑梗死伴肺感染患者血流变学、Lp-PLA2水平及神经功能缺损情况,因此其在脑梗死伴肺感染患者中的应用价值较高。

OBJECTIVE To study and observe the influence situation of Shuxuening injection for the hemorheology, Lp-PLA2 level and neurologic impairment of patients with cerebral infarction and pulmonary infection,in order to provide evidence for the selection of treatment method of patients with cerebral infarction and pulmonary infection. METHODS A total of 46 patients with cerebral infarction and pulmonary infection in our hospital from Dec. 2013 to Nov. 2015 were selected as the research objects, and 46 cases were divided into control group and observation group with 23 cases in each group by the method of random allocation. The control group were treated with con- ventional treatment of cerebral infarction and pulmonary infection, and the observation group were treated with Shuxuening injection on the treatment of control group. Then the hemorheology,plasma Lp-PLA2 level and nerve function related serum indexes of two groups before the treatment and at seventh and fourteenth day after the treatment were compared. RESULTS The hemorheology, plasma Lp-PLA2 level and nerve function related serum indexes of two groups before the treatment in two groups all had no obvious differences, and the plasma viscosity, whole blood low shear viscosity and whole blood low shear viscosity of observation group at seventh and fourteenth day after the treatment were respectively （1.34±0.12）mPa · s, （8.98 ± 0.84）mPa · s, （20.21 ± 1.64）mPa ·s and（1.10±0.08）mPa · s, （7.82· 0.75） mPa · s, （18. 10±1.25）mPa · s,and they were all lower than （1.78±0.18）mPa · s,（11.21±1.30）mPa · s,（22.45±1.82）mPa · s and（1.45±0.13）mPa · s,（9.94±0.89）mPa· s, （20. 46 ± 1.70）mPa · s of control group, and other hemorheology indexes, plasma Lp-PLA2 level and nerve function related serum indexes were all lower than those of control group,and the differences were all significant （P〈0.05）. CONCLUSION The Shuxuening injection can effectively improve the hemorheology, Lp-PLA2 level and neurologic impairment of patients with cerebral infarction and pulmonary infection,so its application value for the patients with cerebral infarction and pulmonary infection is higher.