阿尔茨海默病淡漠症状研究进展

Progress of nonpharmacologicai interventions in the treatment of apathy in Alzheimer＇s disease

淡漠是阿尔茨海默病患者最常见的神经精神症状之一，对患者产生严重的负面影响。目前尚没有针对淡漠的特效药物治疗，因此非药物干预的研究日益受到人们的关注，如音乐疗法、怀旧疗法、多感官刺激疗法、运动疗法、作业疗法和理疗法等对淡漠症状均能起到一定的改善作用。但国内外专门针对淡漠症状而开展干预性研究的报道依然很少，非药物干预的方法应进一步系统规范化，并值得在临床推广使用。

Apathy is one of the most common neuropsychiatric symptoms in patients with Alzheimer＇s disease. Apathy has a serious negative impact on patients. There have been no specific medicines for treatment of apathy. Accordingly, people have become increasingly concerned about the study of nonpharmacological interventions. Multiple non-pharmacological therapies such as music therapy, reminiscence therapy, multi-sensory stimulation, exercise therapy, occupational therapy and physiotherapy have played a role in improving the symptoms of apathy. However, the intervention study aiming at apathy is rarely reported at home and abroad. The method of non-pharmacological interventions should be further standardized, and it is worthy of clinical application.