槐耳颗粒对乳腺癌术后患者T细胞亚群的影响

Effect of Huaier granule on T lymphocyte subsets in patients after breast cancer surgery

目的观察槐耳颗粒对乳腺癌术后患者外周血T淋巴细胞亚群的影响。方法经病理学检查确诊的乳腺癌术后患者90例随机分为两组,治疗组45例,应用"FEC"方案化疗(环磷酰胺0.6/m2,静脉推注,d1,表柔比星100 mg/m^2,静脉滴注,d1,5-氟尿嘧啶0.6/m^2,静脉滴注,d1,共6周期),化疗同时加用槐耳颗粒口服,20 g/次,3次/d,21 d为1个周期;对照组45例,单纯行"FEC"方案化疗,化疗前、后测定患者外周血NK细胞、CD3^+、CD4^+、CD4^+/CD8^+比值。结果治疗组治疗后外周血NK细胞、CD3^+、CD4^+、CD4^+/CD8^+比值均高于治疗前,差异有统计学意义(P<0.05);对照组治疗前、后各值差异无统计学意义(P>0.05);治疗组治疗后其值明显优于对照组,差异有统计学意义(P<0.05)。结论槐耳颗粒能提高乳腺癌术后化疗患者的免疫功能,而且无明显不良反应,值得临床进一步观察。

Objective To observe the effect of Huaier granule on T lymphocyte subsets in peripheral blood of patients after breast cancer surgery. Methods Ninety patients were diagnosed as breast cancer definitely by pathological examination,then breast cancer surgery was performed. All the patients were randomly divided into two groups. Forty-five patients in treatment group were treated by FEC chemotherapy regimen（ intravenous injection of cyclophosphamide 0. 6 / m^2,d1,intravenous drip of epirubicin 100 mg/m^2,d1,intravenous drip of 5-fluorouracil 0. 6 / m^2,d1,6 courses of treatment totally）,at the same time of chemotherapy,the patients were treated by oral administration of Huaier granule,20 g per time,three times per day,one course of treatment included 21 days. Forty-five patients in control group were treated by FEC chemotherapy regimen. Before and after chemotherapy,blood NK cells,CD3^＋cells,CD4^＋cells,CD4^＋/ CD8^＋ratio were detected. Results Blood NK cells,CD3^＋cells,CD4^＋cells,CD4^＋/ CD8^＋ratio after chemotherapy in treatment group were statistically significantly higher than those before treatment（ P〈0. 05）. In control group,there was no statistically significant difference between before and after treatment（ P〉0. 05）. After chemotherapy,blood NK cells,CD3^＋cells,CD4^＋cells,CD4^＋/ CD8^＋ratio in treatment group were statistically significantly better than those in control group（ P 〈0. 05）. Conclusion Huaier granule can increase immune function of breast cancer patients after postoperative chemotherapy without significant adverse reactions,which is worthy of further clinical observation.