GNB3 C825T基因多态性及其与饮食运动的交互作用对产后体格状况影响的研究

Study on the effects of GNB3 C825T gene polymorphism and its interaction with diet and exercise on postpartum physical condition

目的研究GNB3 C825T基因多态性与产后体格状况的相关性,并探究饮食、运动等因素与该基因的交互作用对产后体格状况的影响。方法选取2014年5-11月在包头市及巴彦淖尔市地区医院分娩的154名健康单胎产妇为研究对象。于产后12个月对其进行问卷调查及血样采集,利用PCR-RFLP方法检测基因型。结果产后12个月GNB3基因TT与CC/CT基因型组间产妇体重滞留量差异有统计学意义(P<0.05),TT与CC/CT基因型频率分布在体重指数(BMI)正常组和超重/肥胖组间差异无统计学意义(P>0.05)。Logistic回归分析结果显示:初产情况、文化程度、孕前BMI及每日总能量摄入是产后超重/肥胖的影响因素(P<0.05),基因型与产后体力活动锻炼、每日总能量摄入及静坐间的交互作用对产后超重/肥胖无影响(P>0.05)。结论 GNB3 C825T基因多态性影响产后体重滞留量,基因型与产后体力活动锻炼、每日总能量摄入、静坐间的交互作用对产后超重/肥胖无影响。

Objective To study the correlation between GNB3 C825 T gene polymorphism and postpartum physical condition,explore the effects of GNB3 C825 T gene polymorphism interaction with diet and exercise on postpartum physical condition. Methods A total of 154 healthy women of single pregnancy giving birth to their babies in hospitals of Baotou city and Bayannur city from May to November in 2014 were selected as study object,questionnaire survey and blood specimen collection were conducted after 12 months of birth,PCR-RFLP was used to detect genotypes. Results There was statistically significant difference in maternal weight retention amount between GNB3 TT genotype and CC / CT genotype after 12 months of birth（ P〈0. 05）,there was no statistically significant difference in the frequencies of GNB3 TT and CC / CT genotypes between pregnant women with normal body mass index（ BMI） and overweight / obese pregnant women（ P 〉0. 05）.Logistic regression analysis showed that primiparity,educational level,pregnancy BMI,and total daily energy intake were influencing factors of postpartum overweight / obesity（ P〈0. 05）. The interactions between genotype and postpartum physical activity,total daily energy intake,meditation had no significant impact on postpartum overweight / obesity（ P〉0. 05）. Conclusion GNB3 C825 T gene polymorphism affects postpartum weight retention amount; the interactions between genotype and postpartum physical activity,total daily energy intake,exercise,meditation has no significant impact on postpartum overweight / obesity.