阿托伐他汀对冠心病患者超敏-C反应蛋白、同型半胱氨酸及颈动脉内膜-中层厚度的影响

Effect of atorvastatin on high-sensitivity C-reactive protein,hemocysteine and intima-media thickness of carotid artery in patients with coronary heart disease

目的观察阿托伐他汀对冠心病患者血超敏-C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)及颈动脉内膜-中层厚度(IMT)的影响。方法冠心病患者150例,采用随机数字表法分为观察组和对照组,每组75例,两组患者均予常规对症治疗,观察组在常规治疗基础上加用阿托伐他汀,疗程6个月。比较两组患者治疗前后血脂(TC、TG、LDL-C、HDL-C)、hs-CRP、Hcy水平及颈动脉IMT的变化。结果治疗后两组患者TC、TG、LDL-C水平较治疗前降低,HDL-C水平升高,且观察组患者TC、TG、LDL-C水平低于对照组,HDL-C水平高于对照组(P均<0.05)。治疗后两组患者hs-CRP、Hcy、颈动脉IMT水平较治疗前明显降低(P<0.05),且观察组的以上指标低于对照组(P<0.05)。结论阿托伐他汀可以降低冠心病患者血脂水平,抑制炎性反应,延缓或阻止动脉硬化发展。

Objective To observe the effect of atorvastatin on high-sensitivity C-reative protein（ hs-CRP）,hemocysteine（ Hcy）and intima-media thickness（ IMT） of carotid artery in patients with coronary heart disease. Methods A total of 150 patients were divided into observation group and control group using a random number table,with 75 cases in each group. The routine symptomatic treatment was performed in both groups. And the observation group was orally administered atorvastatin on the basis of the routine treatment. The therapeutic course was 6 months. Before and after treatment,the levels of blood lipid（ including TC,TG,LDL-C,and HDL-C）,hs-CRP and Hcy,and carotid arterial IMT were compared between the two groups. Results After treatment,the levels of TC,TG and LDL-C decreased while HDL-C level increased in both groups,and the levels of TC,TG and LDL-C were lower and HDL-C level was higher in the observation group compared to the control group（ all P〈0. 05）. After treatment,the hs-CRP,Hcy and carotid arterial IMT decreased in both groups（ P〈0. 05）,and the indices were lower in the observation group compared to the control group（ P〈0. 05）. Conclusion Atorvastatin can reduce the blood lipid level,inhibit inflammatory reaction,and delay or prevent the progression of atherosclerosis in patients with coronary heart disease.