1450例婴幼儿和学龄前儿童的呼出气一氧化氮检测水平分析

Analysis on detection level of fractional exhaled nitric oxide in 1450 infants and preschool children

目的了解婴幼儿和学龄前儿童的呼出气一氧化氮（FeNO）检测水平。方法选取1 450例儿童,年龄3 d至6岁,男性935例、女性515例,检测FeNO水平,比较不同性别、不同年龄段儿童的FeNO水平。结果 1 450名婴幼儿和学龄前儿童FeNO水平为（11.14±6.18）ppb,95%CI[10.91,11.38];男性FeNO水平为（10.90±5.55）ppb,低于女性的（11.54±7.08）ppb（P〈0.05）。各年龄段儿童FeNO水平比较,差异有统计学意义（P〈0.05）,其中〉2-3岁儿童的FeNO水平最高,其次为新生儿。结论婴幼儿及学龄前儿童FeNO水平波动范围平稳,不同年龄段儿童FeNO水平不同,年龄可能是影响FeNO水平的重要因素之一。

Objective To explore the detection level of fractional exhaled nitric oxide（ FeNO） in infants and preschool children.Methods A total of 1 450 children aged from 3 days to 6 years were enrolled,including 935 males and 515 females. The FeNO levels were measured,and were compared among children with different gender or age brackets. Results The FeNO level of 1 450 infants and preschool children was（ 11. 14 ± 6. 18） ppb（ 95% CI[confidence interval]： 10. 91,11. 38）. The FeNO level of the male was（ 10. 90 ± 5. 55） ppb,and was lower than that of the female[（ 11. 54 ± 7. 08） ppb,P〈0. 05]. There was a statistical difference in the FeNO level among children with different age brackets（ P〈0. 05）. And the FeNO level was the highest in the children aged from 2 to 3 years,and was the second highest in the neonates. Conclusion The fluctuation range of FeNO level is stable in infants and preschool children. There is a difference in the FeNO level among children with different age brackets,and age may be one of important factors influencing FeNO level.