垂体细胞瘤3例临床病理观察

Pituicytoma: report of three cases and review of literatures

目的探讨垂体细胞瘤的临床表现、病理学特征和免疫组化特点。方法对4例垂体细胞瘤进行光镜下观察,通过临床随访及结合文献复习进行讨论。结果本组男性2例,女性1例,年龄45～54岁。大体表现为实性肿瘤。镜下由双极梭形细胞构成,束状交错排列,有时旋涡状。瘤细胞纺锤状至胖细胞状不等。免疫组化：肿瘤细胞vimentin、S-100和TTF-1（＋）,GFAP和垂体激素（-）。结论垂体细胞瘤罕见,生长缓慢,属于WHO I级。需与毛细胞型星形细胞瘤、脑膜瘤等相鉴别。

Objective To discuss the clinical presentation,clinicopathological characteristics and immunophenoypes of the pituicytoma. Methods Three cases of pituicytoma were investigated under light microscope. Pathological and clinical data were analyzed with review of literature. Results The patients were 2 males and 1 female. The age of patients ranged from 45 to 54 years. On gross examination,the tumors were solid. Microscopically,pituicytoma was almost composed of cambiform or chubby bipolar fusiform cells arranged in fascicular clusters. Immunohistochemical study showed that the tumor cells in all cases were positive for vimentin,S-100,TTF-1. All tumors were negative for GFAP and pituitary hormone. Conclusion Pituicytoma is rare. The tumors usually progress slowly（ WHO grade I） and need to be distinguished from hair cell astrocytoma,meningioma and so on.