原发于阴道的子宫内膜间质肉瘤临床病理观察

Endometrial stromal sarcoma arising primarily in vagina: a clinicopathological analysis

目的探讨发生于子宫外的子宫内膜间质肉瘤(ESS)的病理组织学特征。方法通过光镜及免疫组化染色分析1例阴道原发的ESS,同时复习相关文献。结果原发于阴道的ESS与发生于子宫内的ESS形态十分相似,并找到了子宫内膜异位病灶,进一步证明了肿瘤的来源。结论 ESS是一种少见的肿瘤,发生在子宫以外部位就更为罕见,若肿瘤细胞分化差就极易误诊。免疫组化有助于诊断,但亦有片面性,须结合形态学。

Objective To study the pathologic features of extrauterine endometrial stromal sarcoma（ ESS）. Methods A case of ESS of vagina was studied by using light microscopy and immunohistochemical staining,with review of the relevant literatures. Results ESS of vagina was similar to uterine ESS. Endometriosis was found in this case,so the origin of ESS could be confirmed. Conclusions ESS is an uncommon tumor,and extrauterine ESS is much rare. ESS with poor morphological differentiation is always mistaken in diagnosis. Immunohistochemical staining could help the diagnosis of ESS, but it has some limitation. ESS should be diagnosed by morphological observation except for immunohistochemical staining.