慢性活动型EB病毒感染的致病机理研究进展

Current Advances in The Pathogenesis Research of Chronic Active Epstein Barr Virus Infection

慢性活动型EB病毒(Epstein Barr virus,EBV)感染(chronic active EBV infection,CAEBV)是一类EBV相关的T/NK淋巴细胞增殖性疾病(Epstein Barr virus-associated T/NK-cell lymphoproliferative diseases,EBV^+T/NK-cell LPD),以持续反复的类似传染性单核细胞增多症(infectious mononucleosis,IM)临床病征和EBV感染细胞的克隆性增殖为主要特征,在临床上具有较高的发病率和致死率.目前对于CAEBV与其他各类EBV相关的T/NK淋巴细胞增殖性疾病之间的界定以及致病机理的研究仍处于发展阶段,临床上对于该类疾病的治疗也无完全有效的手段.本文主要从EBV如何感染T/NK细胞、EBV相关的病毒学研究、机体自身遗传及免疫背景几方面,综述了目前对于CAEBV致病机理的研究进展,旨在为进一步研究提供思路和线索.

Chronic active Epstein Barr virus infection（CAEBV） is subcategorized as EBV^＋T/NK lymphoproliferative diseases（EBV^＋T/NK-cell LPD） and characterized by recurrent or chronic symptoms of infectious mononucleosis and clonal expansion of EBV^＋T/NK cells and with high morbidity and mortality in clinic. It remains unclear what is the cause of CAEBV due to its complexity among different cases. Clinically, it is of importance to give accurate classification of EBV^＋T/NK-cell LPD for appropriate therapeutic strategy, however,the standards for classification are still unsettled and the treatments are less than satisfactory. To explore some clues for further study, the current understanding of the pathogenesis of CAEBV will be summarized from several aspects such as the clonal expansion of EBV infected cells, EBV related virological factors, defects in host immune system in this review.