表观扩散系数ADC值与直肠癌侵袭性的相关性分析

A correlation analysis between apparent diffusion coefficient value and the invasiveness of rectal cancer

目的:探讨3.0T磁共振扩散加权成像(DWI)的参数表观扩散系数(ADC)与直肠癌侵袭性之间的相关性。方法:对60例经病理证实的直肠癌患者行常规盆腔MRI及DWI扫描,测量整个肿瘤的ADC值。根据MRI图像及术后病理结果,得到肿瘤的病理类型、分化程度、T1-2(肿瘤局限于肠壁)与T3-4(肿瘤生长突破肠壁);N0(无淋巴结转移)与N1-2(有淋巴结转移);CRM阴性(无直肠系膜筋膜浸润)与CRM阳性(有直肠系膜筋膜浸润)、肿瘤的大体分型、部位、年龄及性别,进行相关性比较。结果:直肠癌的ADC值在分化程度(P=0.000)、T1-2与T3-4(P=0.015)、N0与N1-2(P=0.001)、直肠系膜筋膜受累与未受累(P=0.014)之间的差异均有统计学意义。与肿瘤的大体分型(P=0.971)、部位(P=0.960)、性别(P=0.592)、年龄(r=0.038,P=0.772)之间的差异无统计学意义。结论:直肠癌的ADC值可以作为评价其侵袭性及预后的一个定量指标。

Objective：To investigate the correlation between the parameters of the apparent diffusion coefficient（ADC）of the magnetic resonance diffusion weighted imaging（DWI）and invasiveness of rectal cancer.Methods：60cases of rectal cancer patients underwent pelvic routine MRI and DWI imaging.The ADC value was measured for the whole tumor.Also according to MRI and pathological results,the correlation was analyzed between the rectal cancer pathological type,degree of differentiation,pathological T and N staging,mesorectal fascia involvement,tumor gross type,tumor position,and age and gender of the patients.Results：The ADC value of rectal cancer was of statistical significance with differentiated degree（P〈0.000）,T1-2and T3-4（P=0.015）,pathology N0 and N1-2（P=0.001）,affected mesorectal fascia and unaffected one（P=0.014）.The ADC value of rectal cancer had no statistical significance with gross type of tumor（P=0.971）,tumor position（P=0.960）,gender（P=0.592）.There is no significant correlation between the ADC value and age（r=0.038,P=0.772）of the patient.Conclusion：The ADC value of rectal cancer can be used as a quantitative index to evaluate the invasiveness and prognosis of tumor.