腹腔镜下卵巢子宫内膜异位症囊肿剥除术前应用亮丙瑞林微球对卵巢储备功能的保护效果

Protective effect of leuprorelin particle application before laparoscopic cystectomy on ovarian reserve function in ovarian endometriosis

目的研究腹腔镜下行卵巢子宫内膜异位症囊肿剥除术患者术前采用亮丙瑞林微球治疗对卵巢功能的影响。方法临床纳入106例2015年1月~2015年12月期间收治的内异症囊肿患者,按随机数字表法将患者分为2组各53例。其中53例患者直接行腹腔镜手术治疗作为对照组,另53例患者先采用亮丙瑞林治疗后再行腹腔镜手术治疗作为观察组。观察2组患者手术情况、卵巢激素水平及功能情况等。结果观察组患者手术时间及出血量均少于对照组（P〈0.05）;2组患者术后排气时间差异无统计学意义。术后观察组卵泡刺激素（follicle stimulating hormone,FSH）水平低于对照组,雌二醇（estradiol,E2）水平高于对照组（P〈0.05）;2组患者黄体生成素（luteinizing hormone,LH）水平差异无统计学意义。术后观察组卵巢体积及窦状卵泡数（antral follicle count,AFC）均优于对照组（P〈0.05）。结论腹腔镜卵巢囊中剥离患者术前应用亮丙瑞林可有效保护卵巢功能及形态,对激素影响较小,手术更方便。

Objective To study the protective effect of leuprorelin particle on ovarian reserve function applied before the laparoscopic cystectomy of ovarian endometriosis. Methods 106 patients with endometriosis treated from January 2015 to December 2015 in our hospital were selected. The subjects were divided into two groups according to the random number table,53 cases of each group. The control group adopted the laparoscopic surgery;the observation group took the leuprorelin particle before the laparoscopic surgery. The operation condition,ovarian hormone and function were observed.Results The operation time and bleeding amount in observation group was better than control group（ p〈0. 05）. After surgery,the exhaust time between two groups had no significantly different. After surgery,the level of follicle stimulating hormone（ FSH） in observation group was lower than control group; the level of estradiol（ E2） in observation group was higher than control group（ p〈0. 05）; the level of luteinizing hormone（ LH）between two groups had no significantly different. After surgery,the ovarian volume and antral follicle count（ AFC） in observation group was better than control group（ p〈0. 05）. Conclusion Before the laparoscopic cystectomy of ovarian endometriosis,the leuprorelin particle protects the ovarian function and morphology and has less impact in the level of hormone.