窖蛋白-1和促红细胞生成素产生肝细胞受体酪氨酸激酶A2在骨肉瘤组织的表达及其临床意义

Expression and clinicopathologic significance of caveolin-1 and erythropoietin producing human hepatocellular receptor A2 in osteosarcoma

目的 探讨骨肉瘤组织中窖蛋白-1（Caveolin-1）和促红细胞生成素产生肝细胞受体（Eph受体）酪氨酸激酶A2（EphA2）的表达及两者与骨肉瘤临床病理特征之间的关系.方法 应用免疫组织化学法检测73例骨肉瘤患者和23例骨软骨瘤患者手术切除组织中Caveolin-1和EphA2表达水平.结果 Caveolin-1在骨肉瘤组织中表达率明显高于骨软骨瘤组织表达率（63.01％比13.04％,P＜0.01）,Caveolin-1表达水平均与骨肉瘤Eneeking分期、肺转移明显相关（P＜0.05）;EphA2在骨肉瘤组织中表达率明显高于骨软骨瘤组织表达率（75.34％比8.70％,P＜0.01）,EphA2表达水平均与骨肉瘤软组织浸润、Eneeking分期、肺转移明显相关（P＜0.05）.结论 检测骨肉瘤组织Caveolin-1和EphA2有助于判断骨肉瘤的生物学行为.

Objective To investigate the expression of caveolin-1 and erythropoietin producing human hepatocellular receptor A2 （EphA2） in osteosarcoma,and their relation to the clinicopathological features.Methods Immunohistochemical method was used to assess the expression of caveolin-1 and EphA2 in 23 cases of osteochondroma tissues and 73 cases of osteosarcoma tissues.Results The expression rate of caveolin-1 in osteosarcoma tissues was significantly higher than that in osteochondroma tissues （63.01% vs.13.04%,P 〈 0.01）.The expression levels of caveolin-1 were related to Eneeking stage and lung metastasis of osteosarcoma （P 〈 0.05）.The expression rate of EphA2 in osteosarcoma tissues was significantly higher than that in osteochondroma tissues （75.34% vs.8.70%,P 〈0.01）.The expression levels of EphA2 were related to soft tissue involvement,Eneeking stage and lung metastasis of osteosarcoma （P 〈 0.05）.Conclusion Detection of caveolin-1 and EphA2 expression in osteosarcoma may help to predict the biological behaviors of osteosarcoma.