癌抗原199在肝脏疾病中的基础研究进展

Research advances on carbohydrate antigen 199 in liver diseases

癌抗原199（CA199）是一种唾液黏蛋白,在健康人胰腺、胆管上皮等部位广泛存在,其升高与胰腺癌、胃癌、结直肠癌等密切相关,可作为消化道恶性肿瘤,尤其是胰腺癌和胃癌的诊断指标.近年研究结果表明,CA199在不同肝脏疾病中也存在不同程度的升高.现就CA199在不同肝脏疾病中的表达、相关机制及有关意义作一综述.

Carbohydrate antigen 199 （CA199） is a kind of sialomucin,which is widely expressed in pancreas,epithelium of bile duct and other places of the healthy body.The rising level of CA199 is associated with pancreatic cancer,gastrointestinal cancer and colorectal cancer,so it acted as an aid in the diagnosis and monitoring of patients with digestive system cancers,especially in pancreatic cancer and gastric cancer in the past.But recent studies found that CA199 in patients with different liver diseases also have different expression levels.In this article,we review the expression levels,related mechanisms and the significance of CA199 in different liver diseases.