产后抑郁与雌激素α受体基因多态性的相关性及社会心理因素研究

Correlation between the gene polymorphism of estrogen receptor α and postpartum depression and its related social psychological factors

目的探讨产后抑郁与雌激素α受体基因多态性及社会心理因素的相关性。方法选取2015年6月至2015年12月,我院产科收治的产后抑郁产妇为观察组(n=53),选取同期未出现产后抑郁的产妇为正常对照组(n=53)。检测两组产妇雌激素α受体基因PvuⅡ位点多态性,分析可能与产后抑郁相关的社会心理因素。结果雌激素α受体基因PvuⅡ位点表现为PP/Pp/pp三种基因型。对照组PP、Pp和pp基因型所占比例分别为24.53%、33.96%和41.51%,观察组对应基因型占比例分别为37.74%、45.28%和16.98%,两组基因型分布差异具有统计学意义(x^2=7.794,P=0.020)。对照组和观察组P和p等位基因频率分别为41.51%、58.49%和60.38%、39.62%,两组等位基因分布频率差异具有统计学意义(χ~2=7.550,P=0.006)。携带P等位基因(PP+Pp)产妇产后抑郁的发病率最高(P=0.006)。在胎儿性别、产妇工作状态、夫妻关系及婆媳关系等方面,观察组和对照组产妇差异具有统计学意义(P<0.05)。结论产后抑郁发病风险可能与雌激素α受体基因PvuⅡ位点多态性相关;胎儿性别、产妇工作状态、夫妻关系及婆媳关系可能是产妇出现产后抑郁的重要影响因素。

Objective To investigate the correlation between the gene polymorphism of estrogen receptorαand postpartum depression and the social psychological factors. Methods A total of 53 patients with postpartum depression and 53 cases of healthy volunteer from June 2015 to December 2015 in our hospital were selected as research objects. The polymorphism of estrogen receptor α Pvu II gene of all objects was detected by PCR-RFLE and the social psychological factors on the postpartum depression were analyzed. Results The estrogen receptor α Pvu II gene showed PP/Pp/pp gene types. The PP, Pp and pp in control group were accounted as 24.53%, 33.96% and 41.51%, respectively, and those in observation group were accounted 37.74%, 45.28% and 16.98%, respectively. There was statistically difference between two groups （χ2=7.794, P=0.020）. The frequency of P and p allele in the observation group and the control group were 60.38%, 39.62% and 41.51%, 58.49%, respectively. There was statistically significant difference between two groups （χ2=7.550, P=0.006）. In addition, genotype P （PP＋Pp） might increase the risk of the disease （P=0.006）. Gender, working state, relationship between husband and wife, relationship between mother-in-law and daughter-in-law of the two groups existed significant difference （P〈0.05）. Conclusion Postpartum depression may be associated with the polymorphism of estrogen receptor α Pvu II gene. Gender, working state, relationship between husband and wife, relationship between mother-in-law and daughter-in-law may be important factors affecting the disease.