EB病毒在原发性干燥综合征发病机制中的研究进展

Roles of Epstein-Barr virus in the pathogenesis of primary Sjogren′s syndrome

原发性干燥综合征（ primary Sj？gren′s syndrome, pSS）是一种慢性自身免疫性疾病,可累及全身多个系统,迄今pSS的具体发病机制仍未阐明。 EB病毒（ Epstein-Barr virus,EBV）也称人类Ⅳ型疱疹病毒,属于疱疹病毒属,研究发现EBV和pSS的发病有关。随着研究的不断深入,关于EBV致pSS发病的新证据和新观点越来越多,其可能通过多种途径参与pSS发病。本文对pSS发病机制中EBV致病作用的相关研究进行综述。

Primary Sj？gren′s syndrome （ pSS） is a kind of chronic autoimmune disease affecting many organs of the body. The pathogenesis of pSS is still debated. Epstein-Barr virus（EBV）, also called human herpesvirus-4, belongs to the herpesviridae family. Researchers have found that EBV is associated with pSS. With the deepening of researches, more evidences and opinions about the participation of EBV in the pathogenesis of pSS have emerged. EBV can cause the development of pSS in multiple ways. In this re-view, we summarize the roles of EBV in the pathogenesis of pSS.