摘要
AIM：To investigate the prevalence of ophthalmological extra-intestinal manifestations（O-EIMs） in Chinese patients with inflammatory bowel disease（IBD） and to identify risk factors for the development of O-EIMs.METHODS：The study population consisted of Chinese patients with a definite diagnosis of Crohn＇s disease（CD） or ulcerative colitis（UC） in a large teaching hospital between January 1995 and December 2014.Demographic and clinical characteristics of patients were extracted retrospectively.RESULTS： In this twenty-year cohort,645 IBD patients（517 with UC,128 with CD） were registered.Among them122（18.9%） exhibited at least one EIM.Of 13 patients（2.0%） developed O-EIMs,7 of CD（5.5%） and 6 of UC（1.2%）.Clinical ophthalmological manifestations included redness（76.9%）,burning（61.5%）,pain（38.5%）,itching（15.4%） of eyes and vision change（7.7%）.O-EIMs included episcleritis（7）,uveitis（5） and dry eye（1）.OEIMs were more prevalent in female（odds ratio for male0.61,95% confidence interval 0.52-0.73,P 〈0.0001）,and patients who had IBD diagnosis at young age（odds ratio for patients aged 〉30 years 0.76,95% confidence interval0.65-0.88,P 〈0.0001）.CONCLUSION： The frequency of O-EIMs in Chinese patients with IBD is lower than the rates reported in the studies of European and American countries.Episcleritisand uveitis are the most common O-EIMs.O-EIMs are more frequent in patients with CD and more prevalent in female and patients who have IBD diagnosis at young age.
AIM：To investigate the prevalence of ophthalmological extra-intestinal manifestations（O-EIMs） in Chinese patients with inflammatory bowel disease（IBD） and to identify risk factors for the development of O-EIMs.METHODS：The study population consisted of Chinese patients with a definite diagnosis of Crohn＇s disease（CD） or ulcerative colitis（UC） in a large teaching hospital between January 1995 and December 2014.Demographic and clinical characteristics of patients were extracted retrospectively.RESULTS： In this twenty-year cohort,645 IBD patients（517 with UC,128 with CD） were registered.Among them122（18.9%） exhibited at least one EIM.Of 13 patients（2.0%） developed O-EIMs,7 of CD（5.5%） and 6 of UC（1.2%）.Clinical ophthalmological manifestations included redness（76.9%）,burning（61.5%）,pain（38.5%）,itching（15.4%） of eyes and vision change（7.7%）.O-EIMs included episcleritis（7）,uveitis（5） and dry eye（1）.OEIMs were more prevalent in female（odds ratio for male0.61,95% confidence interval 0.52-0.73,P 〈0.0001）,and patients who had IBD diagnosis at young age（odds ratio for patients aged 〉30 years 0.76,95% confidence interval0.65-0.88,P 〈0.0001）.CONCLUSION： The frequency of O-EIMs in Chinese patients with IBD is lower than the rates reported in the studies of European and American countries.Episcleritisand uveitis are the most common O-EIMs.O-EIMs are more frequent in patients with CD and more prevalent in female and patients who have IBD diagnosis at young age.
