TiO_2纳米颗粒稳定的Pickering乳液用作防晒乳成分研究

Pickering emulsions stabilized by TiO_2 nanoparticles for sunscreen formulation

采用烷基化改性的TiO_2纳米颗粒为稳定剂,化妆品级白油为油相,黄芪水溶液为水相,制备了一种载药Pickering乳液。利用TEM、接触角测试仪和光学显微镜对TiO_2纳米颗粒及载药Pickering乳液进行了表征。结果表明,该纳米颗粒分散性良好、尺寸均匀,具备良好的稳定乳液能力;通过紫外吸收测试,控制释放药物和清洗对照实验,表明该载药Pickering乳液具有较高的防晒效果和随光照时间控制释放药物以及易于从皮肤表面清洗的特性。

Medicament- loaded Pickering emulsion was prepared with alkylation modified TiO2 nanoparticles as stabilizer, cosmetic grade white oil as oil phase and Astragalus polysaceharides aqueous solution as water phase. Characterization of the TiO2 nanoparticles and the medicament - loaded Pickering emulsion were carried out by transmission electron microscope （TEM）, contact angle instrument and optical microscope. Results showed the TiO2 nanoparticles display good dispersity, uniform particle size and favorable stabilizing capacity for the emulsions. Results obtained via UV absorbance test, medicament release effect measurement and water rinse experiment indicated that the medicament - loaded Picketing emulsion shows higher sun - screening efficacy, as well as features for controlled medicament release activity according to irradiation time and easy - water rinsing from human skin.