摘要
目的建立诺氟沙星胶囊的微生物限度检查方法。方法按照《中国药典》2015年版规定方法,需氧菌总数检查采用薄膜过滤法,霉菌和酵母菌总数检查采用平皿法,大肠埃希菌检查采用薄膜过滤法。结果各试验菌的回收比值均符合药典规定,控制菌检查中阳性对照试验检出大肠埃希菌。中和剂硫酸镁能有效去除诺氟沙星胶囊的抗菌活性。结论该法可用于诺氟沙星胶囊的微生物限度检查。
OBJECTIVE To establish a microbial limit test method for norfloxacin capsules. METHODS According to Chp2015 method,total aerobic microbial count was checked by membrane filtration method. Total combined yeasts and molds count was checked by plate count. Escherichia coli was checked by membrane filtration method. RESULTS Recovery ratio of each test bacteria were in line with Chp2015. Escherichia coli could be detected in the positive control. CONCLUSION The method can be used for microbial limit test for roxithromycin capsules.
出处
《今日药学》
CAS
2016年第9期633-635,共3页
Pharmacy Today
关键词
诺氟沙星胶囊
微生物限度
中和剂
薄膜过滤
norfloxacin capsules
microbial limit
neutralizer
membrane filtration