恩替卡韦对慢性乙型病毒性肝炎患者TNF-α及CEA水平的影响

Effects of Entecavir on Serum Levels of TNT-α and CEA in Patients with Chronic Viral Hepatitis B

目的:探究恩替卡韦对慢性乙型病毒性肝炎患者TNT-α,CEA水平及临床疗效的影响研究。方法:选取我院慢性乙型病毒性肝炎患者39例,随机分为实验组(20例)和对照组(19例)。对照组予拉米夫定治疗,实验组予恩替卡韦治疗。观察并比较两组患者治疗前后血清TNF-α,CEA及肝功能水平变化以及HBV DNA转阴率。结果:实验组患者的总有效率(95.0%)高于对照组(73.7%),差异有统计学意义(P<0.05);与治疗前相比,两组患者治疗后血清ALT,AST及TNF-α水平均下降,差异具有统计学意义(P<0.05);与对照组比较,实验组患者治疗后血清ALT,AST及TNF-α水平均下降,差异具有统计学意义(P<0.05);与对照组比较,实验组患者HBV DNA转阴率较高,差异有统计学意义(P<0.05)。结论:恩替卡韦治疗慢性乙肝病毒性肝炎的临床效果较好,能够降低TNT-α水平,提高HBV DNA转阴率,改善患者肝功能,值得临床推广应用。

Objective： To investigate the effects of entecavir on serum levels of TNT-α and CEA in patients with chronic viral hepatitis B. Methods： 39 patients with chronic viral hepatitis B from our hospital were collected and randomly divided into experiment group and control group. 19 cases in the control group were treated with lamivudine, while another 20 cases in the experiment group were treated with entecavir. Then the serum levels of TNF-αand CEA, and the liver functions and HBV DNA negative rate of the two groups before and after treatment were observed and compared. Results： The total effective rate of experiment group was 95.0%, which was higher than 73.7% in the control group, and the difference was statistical significance （P〈0.05）; Compared with before treatment, the serum levels ofALT, AST and TNF-a in the two groups decreased, and the experiment group were lower than those of the control group, and the differences were statistically significant （P〈0.05）; Compared with control group, the HBV DNA negative rate of the experiment group was higher, and the difference was statistically significant （P〈0.05）. Conclusion： Entecavir in the treatment of patients with chronic viral hepatitis B can effectively alleviate liver function, speculate that the mechanism is relate to reduce the TNT-α level and increase the negative rate ofHBV DNA.