漳州市先天性甲状腺功能减低症发病现状及影响因素分析

Analysis on incidence of congenital hypothyroidism and related factors in Zhangzhou city

目的分析漳州市新生儿先天性甲状腺功能减低症(CH)的发病情况,分析与CH发病有关的影响因素。方法对漳州市2010-2015年新生儿疾病筛查报表和个案调查表进行描述性分析及统计分析;CH筛查及诊断按照《新生儿疾病筛查技术规范(2010年)》进行。结果漳州市6年间共确诊116例CH患儿,平均发病率31.35/10万,发病率呈较平稳状态;患儿中高龄产妇所生占22.41%;合并甲状腺功能异常产妇所生占7.35%。山区∶沿海∶城区发病率比为3.71∶2.44∶1;未发现CH患儿发病率在性别和出生季节上的差异。结论漳州市6年间CH发病率呈较平稳状态;高龄产妇、合并甲状腺功能异常产妇及山区产妇所生新生儿CH发病率较高。

Objective To investigate the prevalence of neonatal congenital hypothyroidism（CH） and the effect factors. Methods The data of neonatal screening reports and case survey of Zhangzhou from 2010 to 2015 was analyzed. The screening and diagnosis of CH were carried out Technical Specification for Screening of Neonatal Diseases （2010）. Results Among the 6 years, 116 cases of CH were detected , and the prevalence was 31.35 ： 100 000. Of the 116 CH cases, 22.41% and 7.35 % of their mother were high age and thyroid dysfunction when they birth. The prevalence ratio of CH in mountainous area, coastal area and urban was 3.71：2.44：1. There was no difference in gender and season of birth of the children with CH. Conclusion The prevalence of CH in Zhangzhou was steady in recent six years; Mothered with high age, thyroid dysfunction and lived in the mountains have higher prevalence of their children with CH.