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舒更葡糖钠 被引量:7

Sugammadex sodium
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摘要 舒更葡糖钠(Sugammadex sodium)是由默沙东制药公司开发的首个甾体类肌松药的选择性拮抗剂。于2008年首先在瑞典上市,用于逆转由罗库溴铵或维库溴铵导致的肌肉松弛症状。2010年和2015年默沙东制药公司分别向日本和美国递交申请,并于2015年12月15日获美国FDA批准上市[1],商品名为Bridion(布瑞亭)。舒更葡糖钠是一种修饰后的γ-环糊精类化合物。
机构地区 沈阳药科大学
出处 《中国药物化学杂志》 CAS CSCD 2016年第5期433-433,435,共2页 Chinese Journal of Medicinal Chemistry
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  • 1Varela N, Lobato F. Sugammadex and pregnancy,is it safe?[J]. J Clin Anesth, 2014, pii: S0952-8180( 14)00405-5. DOI: 10.1016/ j.jclinane.
  • 2Zwiers A, van den Heuvel M, Smeets J, et al. Assessment of the potential for displacement interactions with sugammadex: a pharmacokinetic -pharmacodynamic modelling approach [J]. Clin Drug Investig, 2011, 31(2): 101-111.
  • 3Peeters P, Passier P, Smeets J, et al. Sugammadex is cleared rapidly and primarily unchanged via renal excretion [J]. Biopharm Drug Dispos, 2011, 32(3): 159-167.
  • 4Cammu G, Van Vlem B, van den Heuvel M, et al. Dialysability of sugammadex and its complex with rocuronium in intensive care patients with severe renal impairment[J]. Br J Anaesth, 2012, 109 (3): 382-390.
  • 5Sorensen MK, Bretlau C, Gatke MR, et al. Rapid sequence induction and intubation with rocuronium-sugammadex compared with succinylcholine: a randomized trial [J]. Br J Anaesth, 2012, 108(4): 682-659.
  • 6McCahon R. Role of sugammadex in rapid sequence induction and intubation[J]. Br J Anaesth, 2012, 109( 1 ) : 123.
  • 7Abrishami A, Ho J, Wong J, et al. Sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade[ J ]. Cochrane Database Syst Rev, 2009, (4) : CD007362. DOI: 10.1002/14651858.CD007362.
  • 8Ezri T, Evron S. Sugammadex and the cannot intubate/cannot ventilate scenario in patients with predicted difficult airway (1)[J]. Br J Anaesth, 2012, 109(3): 459. DOI: 10.1093/bja/aes280.
  • 9Oh YJ, Lee HJ. Multiple cross-reactivity to several types of neuromuscular blocking agents in a patient with rocuronium anaphylaxis[J]. Korean J Anesthesiol, 2013, 65(5): 473-474.
  • 10Baldo BA, McDonnell NJ, Pham NH. Drug-specific cyclodextrins with emphasis on sugammadex, the neuromuscular blocker rocuronium and perioperative anaphylaxis: implications for drug allergy[J]. Clin Exp Allergy, 2011, 41( 12): 1663-1678.

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