agrC对表皮葡萄球菌生物膜形成作用机制的研究进展

Research progress of forming mechanism of agrC on Staphylococcus epidermidis biofilm

表皮葡萄球菌在医用生物材料表面形成的生物膜可有效抵御抗生素的治疗,导致感染迁延不愈,已成为近年来的研究热点.影响生物膜形成的众多基因构成了复杂的调控网络,在生物膜形成的不同阶段发挥不同的作用,其中表皮葡萄球菌附属基因调节子（agr）系统是调节生物膜形成的最重要基因之一.就细菌生物膜的形成过程、agr系统及其相关基因对生物膜形成调控机制的研究现状进行综述,为研究以agr为靶点治疗表皮葡萄球菌生物膜引发的相关感染提供参考.

The formation of Staphylococcus epidermidis biofilm on the surface of medical biomaterials may resist the antibiotics treatment and cause chronic infection,which has become a research focus in recent years.Multiple genes constitute complex regulatory network which affect the biofilm formation,and play different roles in the different stages of biofilm formation.Accessory gene regulator （agr） is one of the most important genes in the process of biofilm formation.The process of bacterial biofilm formation,research status of regulation mechanism of agr system and its related genes in the formation of biofilm are reviewed,to provide reference of using agr as a target for the treatment of staphylococcus epidermidis biofilm related infections.