XPC 基因 rs2228000（C/T）多态性与乳腺癌易感性的Meta分析

Association between XPC rs2228000 （C/T）polymorphism and the susceptibility of breast cancer：a Meta-analysis

目的：定量探讨着色性干皮病 C 组（XPC）基因 rs2228000（C ／T）多态性与乳腺癌易感性之间的关系。方法通过计算机检索 PubMed、Cochrane Library、中国生物医学文献数据库（CBM）、万方医药期刊全文数据库、中国期刊全文数据库（CNKI）及维普数据库（VIP），检索时间截至2015年12月，搜集有关 XPC rs2228000（C ／T）位点多态性与乳腺癌风险的病例对照研究。采用 STATA 12．0软件进行结果分析，计算比值比（OR）和95％CI。结果总共纳入8篇文献，包括9个病例对照研究（3850例乳腺癌患者和5047例健康对照）。纯合子模型（TT vs．CC：OR ＝1．28，95％CI 为1．08～1．52，Z ＝2．80， P ＝0．005）和隐性模型（TT vs．TC ＋CC：OR ＝1．23，95％CI 为1．05～1．43，Z ＝2．64，P ＝0．008）中 XPC rs2228000（C ／T）多态性与乳腺癌易感性有关，而等位基因模型、杂合子模型、显性基因模型中 XPC rs2228000（C ／T）位点多态性与乳腺癌风险无关（P ＞0．05）。在亚洲人群和 PCR-RFLP 亚组的4种基因模型中，XPC rs2228000（C ／T）多态性与乳腺癌易感性有关（T vs．C：OR ＝1．21，95％CI 为1．05～1．40， Z ＝2．63，P ＝0．009；TT vs．CC：OR ＝1．55，95％CI 为1．13～2．13，Z ＝2．70，P ＝0．007；TT ＋TC vs．CC：OR ＝1．26，95％CI 为1．02～1．55，Z ＝2．19，P ＝0．028；TT vs．TC ＋CC：OR ＝1．39，95％CI 为1．04～1．87， Z ＝2．23，P ＝0．026）。基于对照组来源的亚组分析，社区来源的纯合子模型中 XPC rs2228000（C ／T）多态性与乳腺癌发病风险有关（TT vs．CC：OR ＝1．27，95％CI 为1．02～1．57，Z ＝2．16，P ＝0．031）。结论XPC rs2228000（C ／T）多态性可能与乳腺癌风险有关，尤其在亚洲人群中，基因型 TT 可能增加乳腺癌发病风险。

Objective To quantitatively examine the relationship between xeroderma pigmentosum complementation C group （XPC）rs2228000 （C /T）polymorphism and the susceptibility of breast cancer. Methods The relevant case-control studies published up to December 2015 which investigated XPC rs2228000 （C /T）polymorphism and breast cancer risk were identified by searching PubMed,Cochrane Library,Chinese Biomedical Literature Data,Wanfang Database,China National Knowledge Infrastructure and VIP Database. Meta-analysis was conducted using STATA 12.0 software and odds ratio （OR）with its 95%CI were estimated. Results A total of 8 researches involving 9 case-control studies （3 850 breast cancer cases and 5 047 healthy controls） were included.The Meta-analysis showed that there was statistical association between XPC rs2228000（C /T）variance and breast cancer risk in the homozygous model （TT vs.CC：OR =1.28,95%CI：1.08-1.52,Z =2.80,P =0.005）and recessive model （TT vs.TC ＋CC：OR =1.23,95%CI：1.05-1.43, Z =2.64,P =0.008）,but not in the allele model,heterozygote model and dominant model.In the subgroup of ethnicity and genotyping methods,the different significant correlation was existed between them under Asian and PCR-RFLP in genetic models （T vs.C：OR =1.21,95%CI：1.05-1.40,Z =2.63,P =0.009;TT vs.＆amp;nbsp;CC：OR =1.55,95%CI：1.13-2.13,Z =2.70,P =0.007;TT ＋TC vs.CC：OR =1.26,95%CI：1.02-1.55,Z =2.19,P =0.028;TT vs.TC ＋CC：OR =1.39,95%CI：1.04-1.87,Z =2.23,P =0.026）.We also found significant association between them in subgroup of population-based controls in the homozygous model （TT vs.CC：OR =1.27,95%CI：1.02-1.57,Z =2.16,P =0.031）.Conclusion XPC rs2228000 （C /T）polymorphism may be associated with the susceptibility of breast cancer,especially in Asian,and gene-type TT may increase the risk of breast cancer.