摘要
目的:定量探讨着色性干皮病 C 组(XPC)基因 rs2228000(C /T)多态性与乳腺癌易感性之间的关系。方法通过计算机检索 PubMed、Cochrane Library、中国生物医学文献数据库(CBM)、万方医药期刊全文数据库、中国期刊全文数据库(CNKI)及维普数据库(VIP),检索时间截至2015年12月,搜集有关 XPC rs2228000(C /T)位点多态性与乳腺癌风险的病例对照研究。采用 STATA 12.0软件进行结果分析,计算比值比(OR)和95%CI。结果总共纳入8篇文献,包括9个病例对照研究(3850例乳腺癌患者和5047例健康对照)。纯合子模型(TT vs.CC:OR =1.28,95%CI 为1.08~1.52,Z =2.80, P =0.005)和隐性模型(TT vs.TC +CC:OR =1.23,95%CI 为1.05~1.43,Z =2.64,P =0.008)中 XPC rs2228000(C /T)多态性与乳腺癌易感性有关,而等位基因模型、杂合子模型、显性基因模型中 XPC rs2228000(C /T)位点多态性与乳腺癌风险无关(P >0.05)。在亚洲人群和 PCR-RFLP 亚组的4种基因模型中,XPC rs2228000(C /T)多态性与乳腺癌易感性有关(T vs.C:OR =1.21,95%CI 为1.05~1.40, Z =2.63,P =0.009;TT vs.CC:OR =1.55,95%CI 为1.13~2.13,Z =2.70,P =0.007;TT +TC vs.CC:OR =1.26,95%CI 为1.02~1.55,Z =2.19,P =0.028;TT vs.TC +CC:OR =1.39,95%CI 为1.04~1.87, Z =2.23,P =0.026)。基于对照组来源的亚组分析,社区来源的纯合子模型中 XPC rs2228000(C /T)多态性与乳腺癌发病风险有关(TT vs.CC:OR =1.27,95%CI 为1.02~1.57,Z =2.16,P =0.031)。结论XPC rs2228000(C /T)多态性可能与乳腺癌风险有关,尤其在亚洲人群中,基因型 TT 可能增加乳腺癌发病风险。
Objective To quantitatively examine the relationship between xeroderma pigmentosum complementation C group (XPC)rs2228000 (C /T)polymorphism and the susceptibility of breast cancer. Methods The relevant case-control studies published up to December 2015 which investigated XPC rs2228000 (C /T)polymorphism and breast cancer risk were identified by searching PubMed,Cochrane Library,Chinese Biomedical Literature Data,Wanfang Database,China National Knowledge Infrastructure and VIP Database. Meta-analysis was conducted using STATA 12.0 software and odds ratio (OR)with its 95%CI were estimated. Results A total of 8 researches involving 9 case-control studies (3 850 breast cancer cases and 5 047 healthy controls) were included.The Meta-analysis showed that there was statistical association between XPC rs2228000(C /T)variance and breast cancer risk in the homozygous model (TT vs.CC:OR =1.28,95%CI:1.08-1.52,Z =2.80,P =0.005)and recessive model (TT vs.TC +CC:OR =1.23,95%CI:1.05-1.43, Z =2.64,P =0.008),but not in the allele model,heterozygote model and dominant model.In the subgroup of ethnicity and genotyping methods,the different significant correlation was existed between them under Asian and PCR-RFLP in genetic models (T vs.C:OR =1.21,95%CI:1.05-1.40,Z =2.63,P =0.009;TT vs. CC:OR =1.55,95%CI:1.13-2.13,Z =2.70,P =0.007;TT +TC vs.CC:OR =1.26,95%CI:1.02-1.55,Z =2.19,P =0.028;TT vs.TC +CC:OR =1.39,95%CI:1.04-1.87,Z =2.23,P =0.026).We also found significant association between them in subgroup of population-based controls in the homozygous model (TT vs.CC:OR =1.27,95%CI:1.02-1.57,Z =2.16,P =0.031).Conclusion XPC rs2228000 (C /T)polymorphism may be associated with the susceptibility of breast cancer,especially in Asian,and gene-type TT may increase the risk of breast cancer.
出处
《国际肿瘤学杂志》
CAS
2016年第10期752-757,共6页
Journal of International Oncology
基金
甘肃省卫生行业科研计划(GSWST2013-16)
甘肃省科技支撑项目(1504FKCA084)
关键词
乳腺肿瘤
单核苷酸
多态性
META分析
着色性干皮病C组基因
Breast neoplasms
Polymorphism,single nucleotide
Meta-analysis
Xeroderma pigmen-tosum complementation C group gene