氨基末端B型钠尿肽原、同型半胱氨酸和C-反应蛋白在急性脑血管病患者诊治中的作用

The diagnosis value of N-terminal pro-brain natriuretic peptide,homocysteine and C-reactive protein for the patients with acute cerebral vascular disease

目的探讨氨基末端B型钠尿肽原(NT-proBNP)、同型半胱氨酸(Hcy)和C-反应蛋白(CRP)在急性脑血管病(CVD)诊治中的作用。方法检测88例脑出血患者(ICH)和68例脑梗死患者(CI),另选取50例正常对照组,检测血浆NT-proBNP、Hcy和CRP水平,并跟踪观察CVD患者治疗过程中NT-proBNP、Hcy和CRP水平的变化,进行统计分析。结果 CVD组患者NT-proBNP、Hcy和CRP水平较正常对照组明显升高,差异有统计学意义(P<0.01)。ICH组患者CRP水平明显高于CI组,差异有统计学意义(P<0.01),但两组间NT-proBNP和Hcy水平差异无统计学意义(P>0.05)。治疗期间病情恶化发生脑血管意外患者血浆NT-proBNP、Hcy和CRP水平明显高于未发生脑血管意外组,差异有统计学意义(P<0.01)。结论血浆NT-proBNP、Hcy和CRP的水平检测在CVD患者的诊断和治疗中具有十分重要的价值。

Objective To study the application significance of N-terminal pro-brain natriuretic peptide（ NT-proBNP）,homocysteine（ Hcy） and C-reactive protein（ CRP） for the patients with acute cerebral vascular disease（ CVD）. Methods A total of 88 patients with ICH,68 patients with CI and 50 healthy subjects were enrolled for the detection of NT-proBNP,Hcy and CRP levels in plasma. The dynamic changes of NT-proBNP,Hcy and CRP level in CVD patients were followed for the statistical analysis. Results The levels of NT-proBNP,Hcy and CRP in patients with CVD was significantly higher than that in the healthy control group,and the difference was statistically significant（ P 〈 0. 01）. CRP levels in ICH group was higher than that in the CI group,with the difference statistically significant（ P 〈 0. 01）. But there was no statistical significance on the difference in the levels of NT-proBNP and Hcy between the two groups（ P 〉 0. 05）. During the treatment,the plasma levels of NT-proBNP,Hcy and CRP were significantly higher in patients with cerebrovascular accident than in patients without cerebrovascular accident,and the difference was statistically significant（ P 〈 0. 01）. Conclusion Combined detection of the plasma NT-proBNP,Hcy and CRP is valuable in the diagnosis and treatment for the patients with CVD.