期刊文献+

前列腺癌患者血清miR-129、miR-21检测及临床意义 被引量:6

Serological determination and its clinical significance of miRNA-129 and miRNA-21 in prostate cancer patients
原文传递
导出
摘要 目的分析miRNA-129与miRNA-21在前列腺癌患者血清中的表达水平及临床意义。方法采用实时荧光定量PCR检测40例前列腺癌、28例良性肿瘤患者以及12例健康对照者血清miRNA-129与miRNA-21的相对表达水平,分析其表达与临床病理因素的相关性。结果前列腺癌患者组的miRNA-129的相对表达量低于良性肿瘤患者和对照组,且良性肿瘤患者低于对照组,差异均有统计学意义(P<0.01)。前列腺癌患者组的miRNA-21的相对表达量高于良性肿瘤患者和对照组,且良性肿瘤患者高于对照组,差异均有统计学意义(P<0.05)。miRNA-129在肿瘤分化程度越低、病理分期越高的患者中表达水平越低,而miRNA-21则相反。结论 miRNA-129和miRNA-21可作为非侵入性诊断前列腺癌并且判断其病情的分子标志物。 Objective To analyze the serum expression levels and clinical significance of miRNA-129 and miRNA-21 in prostate cancer patients. Methods 40 prostate cancer patients,28 patients with benign prostatic hyperplasia and 12 healthy volunteers were chosen to analyze the expression levels of serum miRNA-129 and miRNA-21,so as to analyze the correlation with the clinical pathological factors. Results The expression of miRNA-129 of patients with benign prostatic hyperplasia was also lower than that of the healthy population,with the differences statistically significant( P 〈 0. 01). The expression of miRNA-21 was higher for prostate cancer patients as compared to the other two groups,while the level of miRNA-21 for patients with benign prostatic hyperplasia was also significantly higher than that in the healthy counterparts,with the differences statistically significant( P 〈 0. 05). The lower the degree of tumor differentiation was,the lower the level of miRNA-129 expression in patients with higher pathological stage was,while miRNA-21 was the opposite. Conclusion miRNA-129 and miRNA-21 can be used as a molecular marker for non-invasive diagnosis of prostate cancer and judging the severity of this disease.
出处 《中国卫生检验杂志》 CAS 2016年第19期2807-2809,共3页 Chinese Journal of Health Laboratory Technology
基金 台州市医学会科学研究基金(TZSYXH15-31)
关键词 miRNA-129 MIRNA-21 前列腺癌 血清学检测 miRNA-129 miRNA-21 Prostate cancer Serological determination
  • 相关文献

参考文献11

二级参考文献125

  • 1Ming Gao,Hao Yin,Zhe-Wei Fei.Clinical application of microRNA in gastric cancer in Eastern Asian area[J].World Journal of Gastroenterology,2013,19(13):2019-2027. 被引量:16
  • 2周桔,罗荣保,汤长发,瞿树林.Bcl-2蛋白家族和p53基因在细胞凋亡中的调控效应[J].中国组织工程研究与临床康复,2007,11(10):1950-1952. 被引量:84
  • 3黎承军,吴苏稼,施鑫.骨肉瘤新辅助化疗疗效评价方法研究进展[J].医学研究生学报,2007,20(11):1211-1213. 被引量:12
  • 4Jemal A, Siegel R,Xu J, et aL Cancer statistics,2010 [J]. CA Cancer J Clin, 2011,61(2): 133-134.
  • 5Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNs as stable blood-based markers for cancer detection J l- Proc Natl Acad Sci USA, 2008,105 (30) : 10513-10518.
  • 6Feldman BJ,Feldman D. The development of androgen-independent prostate cancer [ J ]. Nat Rev Cancer,2001,1 ( 1 ) : 34-45.
  • 7Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay[J]. Nat Rev Genet, 2010,11(9): 597-610.
  • 8Belletti B, Nicoloso MS, Schiappacassi M,et al. p27 (kipl) functional regulation in human cancer: a potential target for therapeutic designs[ J]. Curr Med Chem,2005,12(14) : 1589-1605.
  • 9Chen Y,Zaman MS,Deng G,et al. MicroRNAs 221/ 222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer [ J]. Cancer Prey Res (Phila),2011,4(1) : 76-86.
  • 10De Boer VC, de Goffau MC, Arts IC, et al. SIRT1 stimulation by polyphenols is affected by their stability and metabolism [ J ]. Mech Ageing Dev, 2006,127 (7) : 618-627.

共引文献46

同被引文献75

引证文献6

二级引证文献37

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部