长链非编码RNA在造血系统中的研究进展

Progress in long non-coding RNA in hematopoiesis

长链非编码 RNA（lncRNA）可在遗传水平、转录水平、转录后水平等多层面上通过多种机制调控基因表达，参与生理、病理过程，与多种人类重大疾病关系密切。 lncRNA 在造血细胞成熟、分化过程中也起重要的调控作用，深入探索其作用机制可为血液疾病的诊治提供新思路。

Long non-coding RNAs （lncRNAs） , which are closely related with human critical illness, can regulate gene expression and involve the physiological and pathological processes on epigenetic, transcriptional and post-transcriptional levels through several mechanisms. LncRNAs also play important regulation roles in the maturation and differentiation process of hematopoietic cell. Besides, in-depth exploration of their mechanism will provide new ideas for the diagnosis and treatment of blood diseases.