中性粒细胞/淋巴细胞比值与急性心肌梗死相关性研究被引量：3

Correlation between neutrophil to lymphocyte ratio and coronary lesion severity in patients with acute myocardial infarction

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摘要目的探讨中性粒细胞/淋巴细胞比值(NLR)与急性心肌梗死(AMI)患者冠脉钙化及狭窄严重程度以及GRACE积分的相关性。方法回顾性研究四川省宜宾市第二人民医院2009年11月至2015年12月收治的急性心肌梗死(AMI)患者181例。依据患者冠脉造影术和冠脉CTA结果计算患者Gensini积分和冠脉钙化积分。根据NLR水平将AMI患者分为高NLR组和低NLR组。结果高NLR组比低NLR组具有更高的Gensini积分[(88±41)∶(66±27),P<0.05]、冠脉钙化积分[(285±85)∶(156±73),P<0.05]及GRACE积分[(121±25)∶(103±13),P<0.05]。NLR与Genisi积分(r=0.253,P<0.05)、冠脉钙化积分(r=0.316,P<0.05)与GRACE积分(r=0.189,P<0.05)均呈正相关。逐步多元线性回归显示:NLR、GRACE积分、年龄与糖尿病史为Genisi积分的独立影响因素;NLR、GRACE积分与糖尿病史为冠脉钙化积分的独立影响因素。结论 NLR与AMI患者冠脉钙化及狭窄严重程度以及GRACE积分密切相关,是评估AMI患者疾病严重程度的良好工具。 Objective To investigate the correlation of neutrophil to lymphocyte ratio（ NLR） to coronary artery calcification and severity of lesion in patients with acute myocardial infarction（ AMI）. Methods A retrospective study was performed on 181 patients with AMI received in Yibin Second People＇s Hospital from November 2009 to December 2015. Gensini integral and coronary artery calcification integral were calculated according to the results of coronary angiography and coronary artery CTA,and AMI patients were divided into the high NLR group and the low NLR group according to the level of NLR. Results Compared with AMI patients in the low NLR group,level of Gensini score in AMI patients of the high NLR group was higher[（ 88 ± 41） versus（ 66 ± 27）,P〈0. 05],coronary artery calcification score [（ 285 ± 85） versus（ 156 ± 73）,P〈0. 05] and GRACE score [（ 121 ± 25） versus（ 103 ± 13）,P〈0. 05]. There was a positive correlation between NLR and Genisi score（ r = 0. 253,P〈0. 05）,coronary artery calcification score（ r =0. 316,P〈0. 05） and GRACE score（ r = 0. 189,P〈0. 05）. Stepwise multiple linear regression showed that NLR,GRACE score,age and history of diabetes were independent influencing factors of Genisi score. NLR,GRACE score and diabetes history were the independent influencing factors of coronary artery calcification score. Conclusion NLR is closely related to coronary artery calcification,severity of lesion and GRACE score in AMI patients,which can be used as a good tool to assess the severity of disease in AMI patients.

作者吴恽陈洪亮张君海王娟龚杰

机构地区四川省宜宾市第二人民医院影像科

出处《临床军医杂志》 CAS 2016年第9期910-913,共4页 Clinical Journal of Medical Officers

关键词中性粒细胞/淋巴细胞比值急性心肌梗死 GENSINI积分冠脉钙化积分 GRACE积分 Neutrophil and lymphocyte ratio Acute myocardial infarction Gensini score Coronary artery calcification score GRACE score

分类号 R542.22 [医药卫生—心血管疾病]

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