摘要
Sox基因家族是一类具有高度保守序列的转录因子编码基因,其D亚族中主要成员Sox5和Sox6参与调控胚胎发育、神经生长、软骨形成等生长发育过程。近年来关于SoxD亚族与肿瘤的研究逐渐增多,显示SoxD亚族在不同肿瘤类型中发挥着促癌或抑癌的作用;同时D家族成员的表达差异还可以用于鉴别诊断或作为肿瘤预后的分子标记物。本文介绍SoxD亚族中Sox5和Sox6基因结构及功能,并重点阐述两者在肿瘤发生发展中的意义及相关研究进展。
Sox gene family encodes a group of transcriptional factors and is defined by the presence of a highly conserved domain. Sox genes can be classified into several subgroups. The SoxD subgroup mainly consists of Sox5 and Sox6, which involve in the transcription regulation of development process including embryonic development, neural growth and chondrogenesis. Recent studies about the association between SoxD gene family and cancers are increasing and it suggests that SoxD gene family acts as tumor promoter or suppressor in distinctive cancers. Besides, the SoxD gene family can also act as diagnostic or prognostic markers in various tumors. In this paper, the structures and functions of Sox5/6 are introduced and recent advances in the role of Sox5/6 in cancers are summarized.
出处
《解放军医学院学报》
CAS
2016年第10期1103-1105,F0003,共4页
Academic Journal of Chinese PLA Medical School
基金
国家高技术研究发展计划(863计划)(2014AA020607)~~
