喹硫平与利培酮治疗酒精致精神障碍的疗效及安全性对照研究（英文）

A comparison study of Quetiapine and Risperidone's effectiveness and safety on treating alcohol-induced mental disorder

背景:与利培酮相比,喹硫平治疗酒精所致精神障碍的安全性及有效性尚不明确。目标:探讨喹硫平治疗酒精所致精神障碍的临床疗效及安全性。方法:将148例酒精所致精神障碍患者按治疗方式分为观察组75例和对照组73例,观察组给予喹硫平治疗,每日口服3次,平均维持剂量为151.2(27.3)mg/d,治疗周期为6周;对照组予以利培酮口服治疗,每天口服1次,平均维持剂量为2.3(0.9)mg/d,维持治疗6周。分别于治疗前、后用PANSS量表评分,评估患者预后情况,并观察两种疗法治疗过程中的不良反应,评价两种治疗方法的安全性和有效性。结果:观察组患者治疗2周后PANSS量表评分为71.9(10.2)分,较治疗前(82.6(11.4))分明显好转,且优于对照组的76.5(12.8);治疗4周、6周后各项评分均优于对照组,两组比较差异有统计学意义;观察组有效率(94.7%)优于对照组(90.4%);痊愈率(33.3%)明显高于对照组(24.7%),两组比较差异具有统计学意义;观察组和对照组患者出现不良反应的概率分别为13.3%,19.2%,两组比较差异具有统计学意义。结论:喹硫平治疗酒精所致精神障碍的效果优于利培酮,其可快速改善患者症状,且不良反应发生的风险低,是安全有效的。

Background： Compared with Risperidone, Quetiapine＇s effectiveness and safety on treating alcohol-induced mental disorder is still unclear.Aim： To investigate the clinical effectiveness and safety of Quetiapine on treating alcohol-induced mental disorder.Methods： One hundred and forty-eight patients with alcohol-induced mental disorderwere divided into the experimental group（75 patients） and the control group（73 patients） by the treatments they received. The patients in the experimental group were treated with Quetiapine by taking it three times per day orally. The average maintenance dose was 151.2（27.3） mg/d, and the treatment cycle was 6 weeks. On the other hand, the patients in the control group received Risperidone once per day orally with the average maintenance dose being 2.3（0.9） mg/d, and the treatment cycle was 6 weeks too. PANSS scale was used to assess patients＇ prognoses before and after the treatment respectively. The researchers also observed the adverse reactions in both treatment strategies and evaluated the effectiveness and safety of both treatment strategies.Results： The PANSS scale score of the experimental group after two weeks of treatment was 71.9（10.2）, which was clearly better than 82.6（11.4）, the score before treatment; moreover, it was significantly better than the control group＇s score（76.5（12.8））. Also, the experimental group＇s scores after 4 weeks of treatment and 6 weeks of treatment were significantly better than the control group. The experimental group＇s effective rate（94.7%） was higher than the control group＇s（90.4%）; the cure rate of the experimental group（33.3%） was obviously higher than that of the control group（24.7%）, and the difference was statistically significant. The rates of adverse reactions in the experimental and control groups were 13.3% and 19.2% respectively, and they were significantly different from each other.Conclusions： Treating alcohol-induced mental disorder with Quetiapine is more effective than treating it with Risperidone. Quetiapine can improve patients＇ symptoms quickly, and lower the chance of getting adverse reactions. It is effective and safe.