母体高效价IgG类抗-D抗体致新生儿溶血病相关免疫指标检测及其临床意义

Detection of relevant immuno-indexes and their clinical significance of the newborn babie's hemolytic disease caused by the mother's high titer IgG anti-D antibody

目的通过确定怀有畸形儿的孕妇血清中存在的不规则抗体的性质及效价,以评估其引起新生儿溶血病的风险。方法利用微柱凝胶检测法及试管法鉴定孕妇ABO及RH血型,使用试管法和抗人球法对患者血清中的不规则抗体进行筛查鉴定,并测定抗体效价。结果患者血型为"B"dccee,血清中存在Ig G抗-D,效价为2048。结论高效价的抗-D免疫球蛋白可致Rh系统新生儿溶血病。

Objective Through determining the titre of the irregular antibodies in serum of pregnant women with the malformation to assess risk of the newborn＇s hemolytic disease caused by the antibody. Methods The ABO and Rh blood typing with microcolumn gel test and test tube methord were taken,and the titter of the irregular antibodies were detected with anti-human globulin test. Results The blood group of the pregnant women was ＂B＂ dccee,and the titer of anti-D IgG was 2048. Conclusion Of newborn babie＇s hemolytic disease of caused by the pregnant womenJs high titer anti-D IgG.